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Radiotherapy in Periocular Cutaneous Malignancies: A Retrospective Stud


Lazarevic, Diana; Ramelyte, Egle; Dummer, Reinhard; Imhof, Laurence (2019). Radiotherapy in Periocular Cutaneous Malignancies: A Retrospective Stud. Dermatology, 235(3):234-239.

Abstract

BACKGROUND
Due to the importance of function and cosmetics, periocular skin malignancies represent a therapeutic challenge.
OBJECTIVE
To evaluate the safety and efficacy of radiotherapy (RT) treating periocular skin tumors.
METHODS
Data of patients with periocular tumors treated with grenz or soft X-rays at the University Hospital Zurich, Switzerland, between 2009 and 2014 were reviewed. Basal cell carcinoma (BCC) and squamous cell carcinoma (SCC) with associated in situ lesions, cutaneous melanoma, lentigo maligna (LM), cutaneous lymphoma and Kaposi's sarcoma were included in the analysis.
RESULTS
We found 159 periocular lesions in 145 patients. Overall recurrence was highest for actinic keratosis and Bowen's disease (27%), melanoma (17%) and LM (15%), whereas SCC and BCC showed recurrence in 11 and 10%, respectively. 45% of all recurrences occurred within 12 months after treatment, with a median time to recurrence of 13 months (range 3-73).
CONCLUSION
RT, which provides a good therapeutic response with minimal adverse events, is a therapy option for periocular cutaneous malignancies.

Abstract

BACKGROUND
Due to the importance of function and cosmetics, periocular skin malignancies represent a therapeutic challenge.
OBJECTIVE
To evaluate the safety and efficacy of radiotherapy (RT) treating periocular skin tumors.
METHODS
Data of patients with periocular tumors treated with grenz or soft X-rays at the University Hospital Zurich, Switzerland, between 2009 and 2014 were reviewed. Basal cell carcinoma (BCC) and squamous cell carcinoma (SCC) with associated in situ lesions, cutaneous melanoma, lentigo maligna (LM), cutaneous lymphoma and Kaposi's sarcoma were included in the analysis.
RESULTS
We found 159 periocular lesions in 145 patients. Overall recurrence was highest for actinic keratosis and Bowen's disease (27%), melanoma (17%) and LM (15%), whereas SCC and BCC showed recurrence in 11 and 10%, respectively. 45% of all recurrences occurred within 12 months after treatment, with a median time to recurrence of 13 months (range 3-73).
CONCLUSION
RT, which provides a good therapeutic response with minimal adverse events, is a therapy option for periocular cutaneous malignancies.

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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > University Hospital Zurich > Dermatology Clinic
Dewey Decimal Classification:610 Medicine & health
Scopus Subject Areas:Health Sciences > Dermatology
Language:English
Date:2019
Deposited On:08 Aug 2019 07:39
Last Modified:29 Jul 2020 11:02
Publisher:Karger
ISSN:1018-8665
OA Status:Green
Publisher DOI:https://doi.org/10.1159/000496539
PubMed ID:30939473

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