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Developmental expression patterns of erythropoietin and its receptor in mouse brainstem respiratory regions

Schneider Gasser, Edith M; Elliot-Portal, Elizabeth; Arias-Reyes, Christian; Losantos-Ramos, Karen; Khalid, Kasifa; Ogunshola, Omolara; Soliz, Jorge (2019). Developmental expression patterns of erythropoietin and its receptor in mouse brainstem respiratory regions. Respiratory Physiology & Neurobiology, 267:12-19.

Abstract

Erythropoietin (EPO) is a hypoxia-inducible hormone, classically known to enhance red blood cell production upon binding its receptor (EPOR) present on the surface of the erythroid progenitor cells. EPO and its receptor are also expressed in the central nervous system (CNS), exerting several non-hematopoietic actions. EPO also plays an important role in the control of breathing. In this review, we summarize the known physiological actions of EPO in the neural control of ventilation during postnatal development and at adulthood in rodents under normoxic and hypoxic conditions. Furthermore, we present the developmental expression patterns of EPO and EPORs in the brainstem, and with the use of in situ hybridization (ISH) and immunofluorescence techniques we provide original data showing that EPOR is abundantly present in specific brainstem nuclei associated with central chemosensitivity and control of ventilation in the ventrolateral medulla, mainly on somatostatin negative cells. Thus, we conclude that EPO signaling may act through glutamatergic neuron populations that are the primary source of rhythmic inspiratory excitatory drive. This work underlies the importance of EPO signaling in the central control of ventilation across development and adulthood and provides new insights on the expression of EPOR at the cellular level.

Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > Institute of Pharmacology and Toxicology
07 Faculty of Science > Institute of Pharmacology and Toxicology

04 Faculty of Medicine > Zurich Center for Integrative Human Physiology (ZIHP)
05 Vetsuisse Faculty > Veterinärwissenschaftliches Institut > Institute of Veterinary Physiology
Dewey Decimal Classification:570 Life sciences; biology
Scopus Subject Areas:Life Sciences > General Neuroscience
Life Sciences > Physiology
Health Sciences > Pulmonary and Respiratory Medicine
Uncontrolled Keywords:Brain development; Catecholaminergic nuclei; Cytokines; Pre-bötzinger complex
Language:English
Date:1 September 2019
Deposited On:31 Jul 2019 11:59
Last Modified:21 Oct 2024 01:40
Publisher:Elsevier
ISSN:1569-9048
OA Status:Closed
Publisher DOI:https://doi.org/10.1016/j.resp.2019.05.012
PubMed ID:31154093
Project Information:
  • Funder: Fonds de Recherche du Quebec-Sante
  • Grant ID: FQ121919
  • Project Title:
  • Funder: Catalyst Grant
  • Grant ID: SVB-158607
  • Project Title:

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