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Measurement of microvascular cerebral blood volume changes over the cardiac cycle with ferumoxytol-enhanced T2* MRI


Rivera-Rivera, Leonardo A; Johnson, Kevin M; Turski, Patrick A; Wieben, Oliver; Schubert, Tilman (2019). Measurement of microvascular cerebral blood volume changes over the cardiac cycle with ferumoxytol-enhanced T2* MRI. Magnetic Resonance in Medicine, 81(6):3588-3598.

Abstract

PURPOSE
This feasibility study investigates the non-invasive measurement of microvascular cerebral blood volume (BV) changes over the cardiac cycle using cardiac-gated, ferumoxytol-enhanced MRI.
METHODS
Institutional review board approval was obtained and all subjects provided written informed consent. Cardiac gated MR scans were prospectively acquired on a 3.0T scanner in 22 healthy subjects using -weighted sequences with 2D-EPI and 3D spiral trajectories. Images were collected before and after the intravenous administration of 2 doses of ferumoxytol (1 mg FE/kg and 4 mg FE/kg). Cardiac cycle-induced (1/ ) changes (Δ ) and BV changes (ΔBV) throughout the cardiac cycle in gray matter (GM) and white matter (WM) were quantified and differences assessed using ANOVA followed by post hoc analysis.
RESULTS
Δ was found to increase in a dose-dependent fashion. A significantly larger increase was observed in GM compared to WM in both 2D and 3D acquisitions (P < 0.050). In addition, Δ increased significantly (P < 0.001) post versus pre-contrast injection in GM in both MRI acquisitions. Mean GM Δ derived from 2D-EPI images was 0.14 ± 0.06 s pre-contrast and 0.33 ± 0.13 s after 5 mg FE/kg. In WM, Δ was 0.19 ± 0.06 s pre-contrast, and 0.23 ± 0.06 s after 5 mg FE/kg. The fractional changes in BV throughout the cardiac cycle were 0.031 ± 0.019% in GM and 0.011 ± 0.008% in WM (P < 0.001) after 5 mg FE/kg.
CONCLUSION
Cardiac-gated, ferumoxytol-enhanced MRI enables characterization of microvascular BV changes throughout the cardiac cycle in GM and WM tissue of healthy subjects.

Abstract

PURPOSE
This feasibility study investigates the non-invasive measurement of microvascular cerebral blood volume (BV) changes over the cardiac cycle using cardiac-gated, ferumoxytol-enhanced MRI.
METHODS
Institutional review board approval was obtained and all subjects provided written informed consent. Cardiac gated MR scans were prospectively acquired on a 3.0T scanner in 22 healthy subjects using -weighted sequences with 2D-EPI and 3D spiral trajectories. Images were collected before and after the intravenous administration of 2 doses of ferumoxytol (1 mg FE/kg and 4 mg FE/kg). Cardiac cycle-induced (1/ ) changes (Δ ) and BV changes (ΔBV) throughout the cardiac cycle in gray matter (GM) and white matter (WM) were quantified and differences assessed using ANOVA followed by post hoc analysis.
RESULTS
Δ was found to increase in a dose-dependent fashion. A significantly larger increase was observed in GM compared to WM in both 2D and 3D acquisitions (P < 0.050). In addition, Δ increased significantly (P < 0.001) post versus pre-contrast injection in GM in both MRI acquisitions. Mean GM Δ derived from 2D-EPI images was 0.14 ± 0.06 s pre-contrast and 0.33 ± 0.13 s after 5 mg FE/kg. In WM, Δ was 0.19 ± 0.06 s pre-contrast, and 0.23 ± 0.06 s after 5 mg FE/kg. The fractional changes in BV throughout the cardiac cycle were 0.031 ± 0.019% in GM and 0.011 ± 0.008% in WM (P < 0.001) after 5 mg FE/kg.
CONCLUSION
Cardiac-gated, ferumoxytol-enhanced MRI enables characterization of microvascular BV changes throughout the cardiac cycle in GM and WM tissue of healthy subjects.

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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > University Hospital Zurich > Clinic for Neuroradiology
Dewey Decimal Classification:610 Medicine & health
Language:English
Date:June 2019
Deposited On:09 Aug 2019 14:46
Last Modified:25 Sep 2019 00:40
Publisher:Wiley-Blackwell Publishing, Inc.
ISSN:0740-3194
OA Status:Closed
Publisher DOI:https://doi.org/10.1002/mrm.27670
PubMed ID:30756424

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