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Nucleolus and rRNA gene chromatin in early embryo development


Kresoja-Rakic, Jelena; Santoro, Raffaella (2019). Nucleolus and rRNA gene chromatin in early embryo development. Trends in Genetics : Tig, 35(11):868-879.

Abstract

The nucleolus is the largest substructure in the nucleus and forms around the nucleolar organizer regions (NORs), which comprise hundreds of rRNA genes. Recent evidence highlights further functions of the nucleolus that go beyond ribosome biogenesis. Data indicate that the nucleolus acts as a compartment for the location and regulation of repressive genomic domains and, together with the nuclear lamina, represents the hub for the organization of the inactive heterochromatin. In this review, we discuss recent findings that have revealed how nucleolar structure and rRNA gene chromatin states are regulated during early mammalian development and their contribution to the higher-order spatial organization of the genome.

Abstract

The nucleolus is the largest substructure in the nucleus and forms around the nucleolar organizer regions (NORs), which comprise hundreds of rRNA genes. Recent evidence highlights further functions of the nucleolus that go beyond ribosome biogenesis. Data indicate that the nucleolus acts as a compartment for the location and regulation of repressive genomic domains and, together with the nuclear lamina, represents the hub for the organization of the inactive heterochromatin. In this review, we discuss recent findings that have revealed how nucleolar structure and rRNA gene chromatin states are regulated during early mammalian development and their contribution to the higher-order spatial organization of the genome.

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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:05 Vetsuisse Faculty > Department of Molecular Mechanisms of Disease
07 Faculty of Science > Department of Molecular Mechanisms of Disease
Dewey Decimal Classification:570 Life sciences; biology
Scopus Subject Areas:Life Sciences > Genetics
Uncontrolled Keywords:Genetics, early development; genome architecture; heterochromatin; nucleolus; oocyte; rRNA genes
Language:English
Date:1 November 2019
Deposited On:27 Aug 2019 10:39
Last Modified:29 Jul 2020 11:10
Publisher:Elsevier
ISSN:0168-9525
OA Status:Hybrid
Publisher DOI:https://doi.org/10.1016/j.tig.2019.06.005
PubMed ID:31327501
Project Information:
  • : FunderSNSF
  • : Grant ID31003A_173056
  • : Project TitleAnalysis of nucleolus and nucleolar chromatin factors in the regulation of stem cells

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