Header

UZH-Logo

Maintenance Infos

Neurosurgical Relevance and Treatment of the Tumor Border Zone in High-Grade Gliomas


Burkhardt, Jan-Karl. Neurosurgical Relevance and Treatment of the Tumor Border Zone in High-Grade Gliomas. 2014, University of Zurich, Faculty of Medicine.

Abstract

From a neurosurgical perspective the maximal feasible extent of resection in highgrade malignant gliomas is the primary goal and responsibility of the neurosurgeon as an interdisciplinary partner in the treatment concept of this aggressive disease to achieve prolonged patient survival. Progresses in image-guided resection as outlined in this thesis helps to guarantee the planned resection grade even in non-eloquent cases to avoid unpleasant surprises with unintended residuals after surgery. The understanding and treatment of the tumor border zone including the GSCs is important to plan adequately adjuvant therapy especially in tumor infiltrating eloquent areas, which are not feasible for complete resection. In such a scenario the selective intra-arterial cerebral infusion (SIACI) with therapeutic agents as outlined in this thesis is one new adjuvant possibility as an endovascular neurooncology approach to treat tumor remnants with a high selective agent dose through the tumor supplying vessels while decreasing systemic side effects.

Abstract

From a neurosurgical perspective the maximal feasible extent of resection in highgrade malignant gliomas is the primary goal and responsibility of the neurosurgeon as an interdisciplinary partner in the treatment concept of this aggressive disease to achieve prolonged patient survival. Progresses in image-guided resection as outlined in this thesis helps to guarantee the planned resection grade even in non-eloquent cases to avoid unpleasant surprises with unintended residuals after surgery. The understanding and treatment of the tumor border zone including the GSCs is important to plan adequately adjuvant therapy especially in tumor infiltrating eloquent areas, which are not feasible for complete resection. In such a scenario the selective intra-arterial cerebral infusion (SIACI) with therapeutic agents as outlined in this thesis is one new adjuvant possibility as an endovascular neurooncology approach to treat tumor remnants with a high selective agent dose through the tumor supplying vessels while decreasing systemic side effects.

Statistics

Downloads

0 downloads since deposited on 10 Sep 2019
0 downloads since 12 months

Additional indexing

Item Type:Habilitation (monographical)
Communities & Collections:04 Faculty of Medicine > University Hospital Zurich > Clinic for Neurosurgery
Dewey Decimal Classification:610 Medicine & health
Language:English
Date:20 October 2014
Deposited On:10 Sep 2019 14:27
Last Modified:25 Sep 2019 00:45
Number of Pages:34
OA Status:Closed

Download

Closed Access: Download allowed only for UZH members

Content: Published Version
Language: English
Filetype: PDF - Registered users only
Size: 5MB