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Role of intravoxel incoherent motion parameters in gastro-esophageal cancer: relationship with 18F-FDG-PET, CT perfusion and MR perfusion imaging parameters


Schawkat, Khoschy; Sah, Bert-Ram; Ter Voert, Edwin E; Delso, Gaspar; Wurnig, Moritz; Becker, Anton S; Leibl, Sebastian; Schneider, Paul M; Reiner, Cäcilia S; Huellner, Martin W; Veit-Haibach, Patrick (2019). Role of intravoxel incoherent motion parameters in gastro-esophageal cancer: relationship with 18F-FDG-PET, CT perfusion and MR perfusion imaging parameters. The quarterly journal of nuclear medicine and molecular imaging:Epub ahead of print.

Abstract

BACKGROUND Identification of pre-therapeutic predictive markers in gastro-esophageal cancer is essential for individual-oriented treatment. This study evaluated the relationship of multimodality parameters derived from intravoxel incoherent motion method (IVIM), 18F- FDG-PET, CT perfusion and dynamic contrast enhanced MRI in patients with gastro- esophageal cancer and investigated their histopathological correlation.
METHODS Thirty-one consecutive patients (28 male; median age 63.9 years; range 37-84 years) with gastro-esophageal adenocarcinoma (n=22) and esophageal squamous cell carcinoma (n=9) were analyzed. IVIM parameters: pseudodiffusion (D*), perfusion fraction (fp), true diffusion (D) and the threshold b-value (bval); PET-parameters: SUVmax, metabolic tumor volume (MTV) and total lesion glycolysis (TLG); CT perfusion parameters: blood flow (BF), blood volume (BV) and mean transit time (MTT); and MR perfusion parameters: time to enhance, positive enhancement integral, time-to-peak (TTP), maximum- slope-of-increase, and maximum-slope-of-decrease were determined, and correlated to each other and to histopathology.
RESULTS IVIM and PET parameters showed significant negative correlations: MTV & bval (rs = -0.643, p = 0.002), TLG & bval (rs = -0.699, p < 0.01) and TLG & fp (rs = -0.577, p = 0.006). Positive correlation was found for TLG & D (rs = 0.705, p = 0.000). Negative correlation was found for bval & staging (rs = 0.590, p = 0.005). Positive correlation was found for positive enhancement interval & BV (rs = 0.547, p = 0.007), BF & regression index (rs = 0.753, p = 0.005) and for time-to-peak & staging (rs = 0.557, p = 0.005).
CONCLUSIONS IVIM parameters (bval, fp, D) provide quantitative information and correlate with PET parameters (MTV, TLG) and staging. IVIM might be a useful tool for additional characterization of gastro-esophageal cancer.

Abstract

BACKGROUND Identification of pre-therapeutic predictive markers in gastro-esophageal cancer is essential for individual-oriented treatment. This study evaluated the relationship of multimodality parameters derived from intravoxel incoherent motion method (IVIM), 18F- FDG-PET, CT perfusion and dynamic contrast enhanced MRI in patients with gastro- esophageal cancer and investigated their histopathological correlation.
METHODS Thirty-one consecutive patients (28 male; median age 63.9 years; range 37-84 years) with gastro-esophageal adenocarcinoma (n=22) and esophageal squamous cell carcinoma (n=9) were analyzed. IVIM parameters: pseudodiffusion (D*), perfusion fraction (fp), true diffusion (D) and the threshold b-value (bval); PET-parameters: SUVmax, metabolic tumor volume (MTV) and total lesion glycolysis (TLG); CT perfusion parameters: blood flow (BF), blood volume (BV) and mean transit time (MTT); and MR perfusion parameters: time to enhance, positive enhancement integral, time-to-peak (TTP), maximum- slope-of-increase, and maximum-slope-of-decrease were determined, and correlated to each other and to histopathology.
RESULTS IVIM and PET parameters showed significant negative correlations: MTV & bval (rs = -0.643, p = 0.002), TLG & bval (rs = -0.699, p < 0.01) and TLG & fp (rs = -0.577, p = 0.006). Positive correlation was found for TLG & D (rs = 0.705, p = 0.000). Negative correlation was found for bval & staging (rs = 0.590, p = 0.005). Positive correlation was found for positive enhancement interval & BV (rs = 0.547, p = 0.007), BF & regression index (rs = 0.753, p = 0.005) and for time-to-peak & staging (rs = 0.557, p = 0.005).
CONCLUSIONS IVIM parameters (bval, fp, D) provide quantitative information and correlate with PET parameters (MTV, TLG) and staging. IVIM might be a useful tool for additional characterization of gastro-esophageal cancer.

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Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > University Hospital Zurich > Clinic for Diagnostic and Interventional Radiology
04 Faculty of Medicine > University Hospital Zurich > Clinic for Nuclear Medicine
Dewey Decimal Classification:610 Medicine & health
Language:English
Date:5 September 2019
Deposited On:17 Sep 2019 13:34
Last Modified:13 Jan 2020 16:43
Publisher:Edizioni Minerva Medica
ISSN:1824-4785
OA Status:Closed
Publisher DOI:https://doi.org/10.23736/S1824-4785.19.03153-4
PubMed ID:31496202

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