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Immunity, Hypoxia and Metabolism - the ménage à trois of cancer: implications for immunotherapy


Riera-Domingo, Carla; Audigé, Annette; Granja, Sara; Cheng, Wan-Chen; Ho, Ping-Chih; Baltazar, Fátima; Stockmann, Christian; Mazzone, Massimiliano (2020). Immunity, Hypoxia and Metabolism - the ménage à trois of cancer: implications for immunotherapy. Physiological reviews, 100(1):1-102.

Abstract

It is generally accepted that metabolism is able to shape the immune response. Only recently we are gaining awareness that the metabolic crosstalk between different tumor compartments strongly contributes to the harsh tumor microenvironment (TME) and ultimately impairs immune cell fitness and effector functions. The major aims of this review are: i) to provide an overview on the immune system in cancer; ii) to position oxygen shortage and metabolic competition as the ground of a restrictive TME and as important players in the anti-tumor immune response; iii) to define how immunotherapies affect hypoxia/oxygen-delivery and the metabolic landscape of the tumor and iv) vice versa, how oxygen and metabolites within the TME impinge on the success of immunotherapies. By analyzing preclinical and clinical endeavors, we will discuss how a metabolic characterization of the TME can identify novel targets and signatures that could be exploited in combination with standard immunotherapies and can help to predict the benefit of new and traditional immunotherapeutic drugs.

Abstract

It is generally accepted that metabolism is able to shape the immune response. Only recently we are gaining awareness that the metabolic crosstalk between different tumor compartments strongly contributes to the harsh tumor microenvironment (TME) and ultimately impairs immune cell fitness and effector functions. The major aims of this review are: i) to provide an overview on the immune system in cancer; ii) to position oxygen shortage and metabolic competition as the ground of a restrictive TME and as important players in the anti-tumor immune response; iii) to define how immunotherapies affect hypoxia/oxygen-delivery and the metabolic landscape of the tumor and iv) vice versa, how oxygen and metabolites within the TME impinge on the success of immunotherapies. By analyzing preclinical and clinical endeavors, we will discuss how a metabolic characterization of the TME can identify novel targets and signatures that could be exploited in combination with standard immunotherapies and can help to predict the benefit of new and traditional immunotherapeutic drugs.

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Additional indexing

Item Type:Journal Article, refereed, further contribution
Communities & Collections:04 Faculty of Medicine > Institute of Anatomy
Dewey Decimal Classification:570 Life sciences; biology
610 Medicine & health
Scopus Subject Areas:Life Sciences > Physiology
Life Sciences > Molecular Biology
Health Sciences > Physiology (medical)
Uncontrolled Keywords:Physiology (medical), Physiology, Molecular Biology, General Medicine
Language:English
Date:1 January 2020
Deposited On:17 Sep 2019 12:38
Last Modified:14 Aug 2020 00:00
Publisher:American Physiological Society
ISSN:0031-9333
OA Status:Green
Free access at:Publisher DOI. An embargo period may apply.
Publisher DOI:https://doi.org/10.1152/physrev.00018.2019
PubMed ID:31414610

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