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Pathologie: Wirkungen und Nebenwirkungen der Tumor-Immuntherapie


Koelzer, Viktor H; Glatz, Katharina; Weber, Achim; Flatz, Lukas; Cathomas, Gieri; Zippelius, Alfred; Mertz, Kirsten D (2016). Pathologie: Wirkungen und Nebenwirkungen der Tumor-Immuntherapie. Swiss Medical Forum, 16(5152):197-207.

Abstract

Background mmunotherapy has gained importance with the development of new effective cancer treatments. Immune checkpoint inhibitors (ICI) are monoclonal antibodies that promote T‑cell mediated tumor immune rejection. Checkpoint blockade also carries the risk of inducing autoimmune reactions (“immune related adverse events”, irAEs). The diagnosis and classification of irAEs constitute a new and important field in pathology.
Aim Practice-oriented review of the diagnosis and classification of irAEs.
Materials and methods Structured, selective literature review based on PubMed und UpToDate ® online.
Results he most common irAEs affect the skin, the gastrointestinal tract, the liver, and the respiratory system. The correct diagnosis and classification of irAEs by an interdisciplinary care team is essential for appropriate therapy and the prevention of long-term sequelae. Other important irAEs affect the endocrine organs, the heart, the joints, the kidneys and the nervous system. Because of their rarity and/or limited options for bioptic diagnosis, only limited data on the morphology and pathophysiology of these irAEs are currently available. Autopsies carried out after ICI therapy constitute an important element of quality control and allow better documentation of the incidence and pathogenesis of irAEs.
Discussion Pathology plays a central role in the diagnosis and treatment of irAEs. Future studies may contribute to a better mechanistic understanding of irAEs for individualized knowledge-based risk assessment.

Abstract

Background mmunotherapy has gained importance with the development of new effective cancer treatments. Immune checkpoint inhibitors (ICI) are monoclonal antibodies that promote T‑cell mediated tumor immune rejection. Checkpoint blockade also carries the risk of inducing autoimmune reactions (“immune related adverse events”, irAEs). The diagnosis and classification of irAEs constitute a new and important field in pathology.
Aim Practice-oriented review of the diagnosis and classification of irAEs.
Materials and methods Structured, selective literature review based on PubMed und UpToDate ® online.
Results he most common irAEs affect the skin, the gastrointestinal tract, the liver, and the respiratory system. The correct diagnosis and classification of irAEs by an interdisciplinary care team is essential for appropriate therapy and the prevention of long-term sequelae. Other important irAEs affect the endocrine organs, the heart, the joints, the kidneys and the nervous system. Because of their rarity and/or limited options for bioptic diagnosis, only limited data on the morphology and pathophysiology of these irAEs are currently available. Autopsies carried out after ICI therapy constitute an important element of quality control and allow better documentation of the incidence and pathogenesis of irAEs.
Discussion Pathology plays a central role in the diagnosis and treatment of irAEs. Future studies may contribute to a better mechanistic understanding of irAEs for individualized knowledge-based risk assessment.

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Additional indexing

Other titles:The pathology of adverse events with immune checkpoint inhibitors
Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > University Hospital Zurich > Institute of Pathology and Molecular Pathology
Dewey Decimal Classification:610 Medicine & health
Language:English
Date:2016
Deposited On:27 Sep 2019 08:52
Last Modified:29 Sep 2019 05:59
Publisher:EMH Swiss Medical Publishers
ISSN:1424-3784
OA Status:Gold
Free access at:Publisher DOI. An embargo period may apply.
Publisher DOI:https://doi.org/10.4414/smf.2016.02834
PubMed ID:28421272

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