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T-cell infiltrates and tumor budding: promising prognostic factors in the tumor microenvironment of colorectal cancer


Koelzer, Viktor H; Lugli, Alessandro (2013). T-cell infiltrates and tumor budding: promising prognostic factors in the tumor microenvironment of colorectal cancer. Colorectal Cancer, 2(3):173-176.

Abstract

The tumor microenvironment is the battleground of pro- and anti-tumor factors. On the tumor’s side, epithelial–mesenchymal transition (EMT) and tumor budding is the histomorphologic signature of aggressive disease. On the host’s side, T-effector cell infiltrates are the hallmark of an active anti-tumoral immune defense. These morphological features can be measured by the histopathologist and represent important novel histomorphological prognostic factors in colorectal cancer (CRC).

Abstract

The tumor microenvironment is the battleground of pro- and anti-tumor factors. On the tumor’s side, epithelial–mesenchymal transition (EMT) and tumor budding is the histomorphologic signature of aggressive disease. On the host’s side, T-effector cell infiltrates are the hallmark of an active anti-tumoral immune defense. These morphological features can be measured by the histopathologist and represent important novel histomorphological prognostic factors in colorectal cancer (CRC).

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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > University Hospital Zurich > Institute of Pathology and Molecular Pathology
Dewey Decimal Classification:610 Medicine & health
Language:English
Date:2013
Deposited On:26 Sep 2019 11:00
Last Modified:31 Jul 2020 03:39
Publisher:Future Medicine
ISSN:1758-194X
OA Status:Hybrid
Publisher DOI:https://doi.org/10.2217/crc.13.26

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