Header

UZH-Logo

Maintenance Infos

Hormones of the hypothalamic-pituitary-gonadal (HPG) axis in male depressive disorders - A systematic review and meta-analysis


Fischer, Susanne; Ehlert, Ulrike; Amiel Castro, Rita Tatiana (2019). Hormones of the hypothalamic-pituitary-gonadal (HPG) axis in male depressive disorders - A systematic review and meta-analysis. Frontiers in Neuroendocrinology, 55:100792.

Abstract

Sexual dysfunctions are common in men with depression. As the hypothalamic-pituitary-gonadal (HPG) axis is a crucial regulator of sexual function, and also affects mood and cognition, the following question arises: Is the HPG axis altered in depressed men when compared to healthy controls? To answer this question, PubMed and PsycINFO were searched. Inclusion criteria for the systematic review and meta-analysis were: 1) case-control study including male patients with a depressive disorder and 2) assessment of follicle-stimulating hormone (FSH), luteinising hormone (LH), oestradiol, or testosterone. Seventeen studies were identified. Follicle-stimulating hormone and LH did not differ between patients and controls. By contrast, in patients, oestradiol was marginally increased (g=0.52, 95% CI [-0.01, 1.04]; Z=1.92, p=.055) and testosterone was significantly decreased (g=-0.45, 95% CI [-0.80, -0.10]; Z=-2.53, p=.012). Depressed men appear to be characterised by diminished testosterone and potentially elevated oestradiol, which beyond contributing to sexual dysfunction, may impact mood and cognition.

Abstract

Sexual dysfunctions are common in men with depression. As the hypothalamic-pituitary-gonadal (HPG) axis is a crucial regulator of sexual function, and also affects mood and cognition, the following question arises: Is the HPG axis altered in depressed men when compared to healthy controls? To answer this question, PubMed and PsycINFO were searched. Inclusion criteria for the systematic review and meta-analysis were: 1) case-control study including male patients with a depressive disorder and 2) assessment of follicle-stimulating hormone (FSH), luteinising hormone (LH), oestradiol, or testosterone. Seventeen studies were identified. Follicle-stimulating hormone and LH did not differ between patients and controls. By contrast, in patients, oestradiol was marginally increased (g=0.52, 95% CI [-0.01, 1.04]; Z=1.92, p=.055) and testosterone was significantly decreased (g=-0.45, 95% CI [-0.80, -0.10]; Z=-2.53, p=.012). Depressed men appear to be characterised by diminished testosterone and potentially elevated oestradiol, which beyond contributing to sexual dysfunction, may impact mood and cognition.

Statistics

Citations

Dimensions.ai Metrics
11 citations in Web of Science®
10 citations in Scopus®
Google Scholar™

Altmetrics

Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:06 Faculty of Arts > Institute of Psychology
Dewey Decimal Classification:150 Psychology
Scopus Subject Areas:Life Sciences > Endocrine and Autonomic Systems
Language:English
Date:1 October 2019
Deposited On:30 Sep 2019 14:24
Last Modified:29 Jul 2020 11:24
Publisher:Elsevier
ISSN:0091-3022
OA Status:Closed
Publisher DOI:https://doi.org/10.1016/j.yfrne.2019.100792
PubMed ID:31557486

Download

Full text not available from this repository.
View at publisher

Get full-text in a library