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Pattern of failure after adjuvant radiotherapy following extrapleural pneumonectomy of pleural mesothelioma in the SAKK 17/04 trial


Riesterer, Oliver; Frank Ciernik, I; Stahel, Rolf A; Xyrafas, Alexandros; Aebersold, Daniel M; Plasswilm, Ludwig; Mahmut Ozsahin, E; Zwahlen, Daniel R; Nackaerts, Kristiaan; Zimmermann, Frank; Sabrina Stark, L; Weder, Walter; Krayenbuehl, Jérôme; Swiss Group for Clinical Cancer Research (SAKK), ? (2019). Pattern of failure after adjuvant radiotherapy following extrapleural pneumonectomy of pleural mesothelioma in the SAKK 17/04 trial. Radiotherapy and Oncology, 138:121-125.

Abstract

Postoperative radiotherapy after extrapleural pneumonectomy of malignant pleural mesothelioma was investigated in the randomized phase II trial SAKK17/04. The relapse rate within the high and/or low-dose PTV without previous distant failure was 24%, the isolated in-field-relapse rate within the PTVs was 5% and the distant relapse rate outside of the PTVs was 81%. Clinical outcome was mainly determined by distant disease progression outside of the radiation field.

Abstract

Postoperative radiotherapy after extrapleural pneumonectomy of malignant pleural mesothelioma was investigated in the randomized phase II trial SAKK17/04. The relapse rate within the high and/or low-dose PTV without previous distant failure was 24%, the isolated in-field-relapse rate within the PTVs was 5% and the distant relapse rate outside of the PTVs was 81%. Clinical outcome was mainly determined by distant disease progression outside of the radiation field.

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Item Type:Journal Article, refereed, further contribution
Communities & Collections:04 Faculty of Medicine > University Hospital Zurich > Clinic for Oncology and Hematology
Dewey Decimal Classification:610 Medicine & health
Language:English
Date:September 2019
Deposited On:04 Oct 2019 09:54
Last Modified:25 Oct 2019 12:52
Publisher:Elsevier
ISSN:0167-8140
OA Status:Closed
Publisher DOI:https://doi.org/10.1016/j.radonc.2019.05.024
PubMed ID:31252293

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