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GutSelf: Interindividual Variability in the Processing of Dietary Compounds by the Human Gastrointestinal Tract


Walther, Barbara; Lett, Aaron M; Bordoni, Alessandra; Tomás‐Cobos, Lidia; Nieto, Juan Antonio; Dupont, Didier; Danesi, Francesca; Shahar, Danit R; Echaniz, Ana; Re, Roberta; Fernandez, Aida Sainz; Deglaire, Amélie; Gille, Doreen; Schmid, Alexandra; Vergères, Guy (2019). GutSelf: Interindividual Variability in the Processing of Dietary Compounds by the Human Gastrointestinal Tract. Molecular Nutrition & Food Research, 63(21):1900677.

Abstract

Nutritional research is currently entering the field of personalized nutrition, to a large extent driven by major technological breakthroughs in analytical sciences and biocomputing. An efficient launching of the personalized approach depends on the ability of researchers to comprehensively monitor and characterize interindividual variability in the activity of the human gastrointestinal tract. This information is currently not available in such a form. This review therefore aims at identifying and discussing published data, providing evidence on interindividual variability in the processing of the major nutrients, i.e., protein, fat, carbohydrates, vitamins, and minerals, along the gastrointestinal tract, including oral processing, intestinal digestion, and absorption. Although interindividual variability is not a primary endpoint of most studies identified, a significant number of publications provides a wealth of information on this topic for each category of nutrients. This knowledge remains fragmented, however, and understanding the clinical relevance of most of the interindividual responses to food ingestion described in this review remains unclear. In that regard, this review has identified a gap and sets the base for future research addressing the issue of the interindividual variability in the response of the human organism to the ingestion of foods.

Abstract

Nutritional research is currently entering the field of personalized nutrition, to a large extent driven by major technological breakthroughs in analytical sciences and biocomputing. An efficient launching of the personalized approach depends on the ability of researchers to comprehensively monitor and characterize interindividual variability in the activity of the human gastrointestinal tract. This information is currently not available in such a form. This review therefore aims at identifying and discussing published data, providing evidence on interindividual variability in the processing of the major nutrients, i.e., protein, fat, carbohydrates, vitamins, and minerals, along the gastrointestinal tract, including oral processing, intestinal digestion, and absorption. Although interindividual variability is not a primary endpoint of most studies identified, a significant number of publications provides a wealth of information on this topic for each category of nutrients. This knowledge remains fragmented, however, and understanding the clinical relevance of most of the interindividual responses to food ingestion described in this review remains unclear. In that regard, this review has identified a gap and sets the base for future research addressing the issue of the interindividual variability in the response of the human organism to the ingestion of foods.

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Additional indexing

Item Type:Journal Article, refereed, further contribution
Communities & Collections:04 Faculty of Medicine > Epidemiology, Biostatistics and Prevention Institute (EBPI)
Dewey Decimal Classification:610 Medicine & health
Uncontrolled Keywords:Biotechnology, Food Science
Language:English
Date:1 November 2019
Deposited On:16 Oct 2019 09:28
Last Modified:05 Nov 2019 02:04
Publisher:Wiley-VCH Verlag
ISSN:1613-4125
OA Status:Green
Publisher DOI:https://doi.org/10.1002/mnfr.201900677
Official URL:https://onlinelibrary.wiley.com/doi/epdf/10.1002/mnfr.201900677
PubMed ID:31483113

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