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Calcium hydroxide [MAK Value Documentations, 2013]


Bartsch, R; Michaelsen, S; Hartwig, A; MAK Commission; et al; Arand, Michael (2016). Calcium hydroxide [MAK Value Documentations, 2013]. The MAK Collection for Occupational Health and Safety, 1(1):12-25.

Abstract

The German Commission for the Investigation of Health Hazards of Chemical Compounds in the Work Area has derived a maximum concentration at the work place (MAK value) for calcium hydroxide, considering all toxicity endpoints. Available publications are described in detail. The critical effect of calcium hydroxide is irritation of eyes and upper airways. From studies in volunteers with calcium oxide, which is hydrolysed in aqueous media to calcium hydroxide, a MAK value of 1 mg/m3 for the inhalable fraction is derived. Since local effects are critical, calcium hydroxide is assigned to Peak Limitation Category I and as there were no irritation effects after 20 minutes exposure to 2 mg/m3, an excursion factor of 2 is set. Studies with the read‐across calcium oxide show that damage to the embryo or foetus is unlikely when the MAK value for calcium hydroxide is observed, and the substance is assigned to Pregnancy Risk Group C. Calcium hydroxide is neither genotoxic nor carcinogenic. Skin contact is not expected to contribute significantly to systemic toxicity or to lead to sensitization.

Abstract

The German Commission for the Investigation of Health Hazards of Chemical Compounds in the Work Area has derived a maximum concentration at the work place (MAK value) for calcium hydroxide, considering all toxicity endpoints. Available publications are described in detail. The critical effect of calcium hydroxide is irritation of eyes and upper airways. From studies in volunteers with calcium oxide, which is hydrolysed in aqueous media to calcium hydroxide, a MAK value of 1 mg/m3 for the inhalable fraction is derived. Since local effects are critical, calcium hydroxide is assigned to Peak Limitation Category I and as there were no irritation effects after 20 minutes exposure to 2 mg/m3, an excursion factor of 2 is set. Studies with the read‐across calcium oxide show that damage to the embryo or foetus is unlikely when the MAK value for calcium hydroxide is observed, and the substance is assigned to Pregnancy Risk Group C. Calcium hydroxide is neither genotoxic nor carcinogenic. Skin contact is not expected to contribute significantly to systemic toxicity or to lead to sensitization.

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Item Type:Journal Article, not_refereed, original work
Communities & Collections:04 Faculty of Medicine > Institute of Pharmacology and Toxicology
07 Faculty of Science > Institute of Pharmacology and Toxicology
Dewey Decimal Classification:570 Life sciences; biology
610 Medicine & health
Language:English
Date:28 January 2016
Deposited On:17 Oct 2019 09:35
Last Modified:23 Oct 2019 15:10
Publisher:Wiley-VCH Verlag
ISSN:2509-2383
ISBN:9783527600410
OA Status:Closed
Publisher DOI:https://doi.org/10.1002/3527600418.mb130562yole5416

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