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Addendum to: Di(2-ethylhexyl) phthalate (DEHP) metabolites in urine Mono-n-butyl phthalate (MnBP) and mono-iso-butyl phthalate (MiBP) in urine [Biomonitoring Methods, 2015]


Koch, H M; Müller, J; Hoppe, H W; Völkel, W; Göen, T; Hartwig, A; MAK Commission; et al; Arand, Michael (2016). Addendum to: Di(2-ethylhexyl) phthalate (DEHP) metabolites in urine Mono-n-butyl phthalate (MnBP) and mono-iso-butyl phthalate (MiBP) in urine [Biomonitoring Methods, 2015]. The MAK Collection for Occupational Health and Safety:1340-1359.

Abstract

The procedure for the determination of Di‐n‐butyl phthalate (DnBP) and diisobutyl phthalate (DiBP) metabolites corresponds to the HPLC–MS/MS method for the determination of the main metabolites of Di(2‐ethylhexyl) phthalate (DEHP) in the urine of occupationally or environmentally exposed persons. The present method is, therefore, an addendum to the procedure for the determination of the DEHP metabolites [ Koch et al. 2007].

For calibration, aqueous standard solutions spiked with the target analytes [mono‐n‐butyl phthalate (MnBP) and mono‐iso‐butyl phthalate (MiBP)] and the internal standards (d4‐mono‐n‐butyl phthalate and d4‐mono‐iso‐butyl phthalate) are processed and analyzed in the same way as the urine samples.

Abstract

The procedure for the determination of Di‐n‐butyl phthalate (DnBP) and diisobutyl phthalate (DiBP) metabolites corresponds to the HPLC–MS/MS method for the determination of the main metabolites of Di(2‐ethylhexyl) phthalate (DEHP) in the urine of occupationally or environmentally exposed persons. The present method is, therefore, an addendum to the procedure for the determination of the DEHP metabolites [ Koch et al. 2007].

For calibration, aqueous standard solutions spiked with the target analytes [mono‐n‐butyl phthalate (MnBP) and mono‐iso‐butyl phthalate (MiBP)] and the internal standards (d4‐mono‐n‐butyl phthalate and d4‐mono‐iso‐butyl phthalate) are processed and analyzed in the same way as the urine samples.

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Item Type:Journal Article, not_refereed, original work
Communities & Collections:04 Faculty of Medicine > Institute of Pharmacology and Toxicology
07 Faculty of Science > Institute of Pharmacology and Toxicology
Dewey Decimal Classification:570 Life sciences; biology
610 Medicine & health
Language:English
Date:27 April 2016
Deposited On:17 Oct 2019 11:00
Last Modified:23 Oct 2019 15:08
Publisher:Wiley-VCH Verlag
ISSN:2509-2383
ISBN:9783527600410
OA Status:Closed
Publisher DOI:https://doi.org/10.1002/3527600418.bi11781e2115

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