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Hexamethylene diisocyanate, 2,4-toluene diisocyanate, 2,6-toluene diisocyanate, isophorone diisocyanate and 4,4′-methylene diphenyl diisocyanate - Determination of hexamethylenediamine, 2,4-toluenediamine, 2,6-toluenediamine, isophoronediamine and 4,4′-me


Cocker, J; Jones, K; Leng, G; Gries, W; Budnik, L T; Müller, J; Göen, T; Hartwig, A; MAK Commission; et al; Arand, Michael (2017). Hexamethylene diisocyanate, 2,4-toluene diisocyanate, 2,6-toluene diisocyanate, isophorone diisocyanate and 4,4′-methylene diphenyl diisocyanate - Determination of hexamethylenediamine, 2,4-toluenediamine, 2,6-toluenediamine, isophoronediamine and 4,4′-me. The MAK Collection for Occupational Health and Safety, 2(3):1415-1435.

Abstract

The working group “Analyses in Biological Materials” of the Permanent Senate Commission for the Investigation of Health Hazards of Chemical Compounds in the Work Area verified the present biomonitoring method.
The described method allows the simultaneous determination of the metabolites of hexamethylene diisocyanate (HDI), 2,4‐toluene diisocyanate and 2,6‐toluene diisocyanate (TDI), isophorone diisocyanate (IPDI) and methylene diphenyl diisocyanate (MDI) in human urine. After acid hydrolysis the released amines, hexamethylenediamine (HDA), 2,4‐toluenediamine, and 2,6‐toluenediamine (TDA), isophorone diamine (IPDA) and 4,4′‐methylenedianiline (4,4′‐MDA) are extracted from urine, derivatised using heptafluorobutyric anhydride and quantified by NCI‐GC‐MS. The method was extensively validated and the reliability data were confirmed by independent laboratories, which have established and cross‐checked the whole procedure.

Abstract

The working group “Analyses in Biological Materials” of the Permanent Senate Commission for the Investigation of Health Hazards of Chemical Compounds in the Work Area verified the present biomonitoring method.
The described method allows the simultaneous determination of the metabolites of hexamethylene diisocyanate (HDI), 2,4‐toluene diisocyanate and 2,6‐toluene diisocyanate (TDI), isophorone diisocyanate (IPDI) and methylene diphenyl diisocyanate (MDI) in human urine. After acid hydrolysis the released amines, hexamethylenediamine (HDA), 2,4‐toluenediamine, and 2,6‐toluenediamine (TDA), isophorone diamine (IPDA) and 4,4′‐methylenedianiline (4,4′‐MDA) are extracted from urine, derivatised using heptafluorobutyric anhydride and quantified by NCI‐GC‐MS. The method was extensively validated and the reliability data were confirmed by independent laboratories, which have established and cross‐checked the whole procedure.

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Item Type:Journal Article, not_refereed, original work
Communities & Collections:04 Faculty of Medicine > Institute of Pharmacology and Toxicology
07 Faculty of Science > Institute of Pharmacology and Toxicology
Dewey Decimal Classification:570 Life sciences; biology
610 Medicine & health
Language:English
Date:31 July 2017
Deposited On:17 Oct 2019 10:39
Last Modified:23 Oct 2019 14:36
Publisher:Wiley-VCH Verlag
ISSN:2509-2383
ISBN:9783527600410
OA Status:Closed
Publisher DOI:https://doi.org/10.1002/3527600418.bi82206e2217

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