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N-Alkyl-2-pyrrolidones (N-methyl-2-pyrrolidone, N-ethyl-2-pyrrolidone), vapour [Air Monitoring Methods, 2014a]


Breuer, D; Ehmann, E; Rosenberger, W; Hebisch, R; Hartwig, A; MAK Commission; et al; Arand, Michael (2016). N-Alkyl-2-pyrrolidones (N-methyl-2-pyrrolidone, N-ethyl-2-pyrrolidone), vapour [Air Monitoring Methods, 2014a]. The MAK Collection for Occupational Health and Safety, 1(2):1237-1250.

Abstract

This analytical method is a validated measurement procedure for the determination of gaseous N‐methyl‐2‐pyrrolidone (NMP) and N‐ethyl‐2‐pyrrolidone (NEP) and for monitoring their Occupational Exposure Limits (OELs) or MAK values at workplaces. Both personal and stationary sampling can be performed for assessment of workplaces. Sampling is performed by drawing air through an ADS‐type silica gel tube using a suitable flow‐regulated pump with a volumetric flow rate of 20 L/h. Gaseous NMP and/or NEP are adsorbed onto the silica gel. For sample preparation the collected NMP and/or NEP are desorbed from the silica gel with a potassium hydroxide solution in methanol. The sample solutions are analysed by gas chromatography using a nitrogen‐selective detector (NPD) with dibutylamine as internal standard. The quantitative determination is based on calibration functions obtained by means of multiple‐point calibrations. The limit of quantification (LOQ) for both, NMP and NEP is 1.6 µg/mL (absolute 1.6 ng), which corresponds to a relative LOQ of 0.1 mg/m3 based on an air sample volume of 40 L.

Abstract

This analytical method is a validated measurement procedure for the determination of gaseous N‐methyl‐2‐pyrrolidone (NMP) and N‐ethyl‐2‐pyrrolidone (NEP) and for monitoring their Occupational Exposure Limits (OELs) or MAK values at workplaces. Both personal and stationary sampling can be performed for assessment of workplaces. Sampling is performed by drawing air through an ADS‐type silica gel tube using a suitable flow‐regulated pump with a volumetric flow rate of 20 L/h. Gaseous NMP and/or NEP are adsorbed onto the silica gel. For sample preparation the collected NMP and/or NEP are desorbed from the silica gel with a potassium hydroxide solution in methanol. The sample solutions are analysed by gas chromatography using a nitrogen‐selective detector (NPD) with dibutylamine as internal standard. The quantitative determination is based on calibration functions obtained by means of multiple‐point calibrations. The limit of quantification (LOQ) for both, NMP and NEP is 1.6 µg/mL (absolute 1.6 ng), which corresponds to a relative LOQ of 0.1 mg/m3 based on an air sample volume of 40 L.

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Additional indexing

Item Type:Journal Article, not_refereed, original work
Communities & Collections:04 Faculty of Medicine > Institute of Pharmacology and Toxicology
07 Faculty of Science > Institute of Pharmacology and Toxicology
Dewey Decimal Classification:570 Life sciences; biology
610 Medicine & health
Language:English
Date:27 April 2016
Deposited On:17 Oct 2019 11:02
Last Modified:24 Oct 2019 06:52
Publisher:Wiley-VCH Verlag
ISSN:2509-2383
ISBN:9783527600410
OA Status:Closed
Publisher DOI:https://doi.org/10.1002/3527600418.am87250e1816a

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