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Oleic acid [MAK Value Documentation, 2016]


Hartwig, A; MAK Commission; et al; Arand, Michael (2017). Oleic acid [MAK Value Documentation, 2016]. The MAK Collection for Occupational Health and Safety, 2(2):455-460.

Abstract

The German Commission for the Investigation of Health Hazards of Chemical Compounds in the Work Area has re‐evaluated oleic acid [112‐80‐1], which was classified as possible carcinogenic to humans in Carcinogen Category 3A, to derive a maximum concentration at the workplace (MAK value), considering genotoxicity and carcinogenicity. Oleic acid is irritating to the skin if applied repeatedly. It is not mutagenic in vitro, data in vivo are not available. Oleic acid showed skin tumour promoting activity in mice after initiation with 9,10‐dimethylbenzanthracen but not without initiation. In a general evaluation of the skin tumour initiation‐promotion‐test in mice published in 2015, the Commission concluded, that substances which only induce skin tumours after initiation, but not without initiation, do not have to be classified in a Carcinogen Category. Therefore, the former classification of oleic acid is withdrawn. Since it is not possible to derive a MAK value with the available data, oleic acid is assigned to Section II b of the List of MAK and BAT values.

Abstract

The German Commission for the Investigation of Health Hazards of Chemical Compounds in the Work Area has re‐evaluated oleic acid [112‐80‐1], which was classified as possible carcinogenic to humans in Carcinogen Category 3A, to derive a maximum concentration at the workplace (MAK value), considering genotoxicity and carcinogenicity. Oleic acid is irritating to the skin if applied repeatedly. It is not mutagenic in vitro, data in vivo are not available. Oleic acid showed skin tumour promoting activity in mice after initiation with 9,10‐dimethylbenzanthracen but not without initiation. In a general evaluation of the skin tumour initiation‐promotion‐test in mice published in 2015, the Commission concluded, that substances which only induce skin tumours after initiation, but not without initiation, do not have to be classified in a Carcinogen Category. Therefore, the former classification of oleic acid is withdrawn. Since it is not possible to derive a MAK value with the available data, oleic acid is assigned to Section II b of the List of MAK and BAT values.

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Item Type:Journal Article, not_refereed, original work
Communities & Collections:04 Faculty of Medicine > Institute of Pharmacology and Toxicology
07 Faculty of Science > Institute of Pharmacology and Toxicology
Dewey Decimal Classification:570 Life sciences; biology
610 Medicine & health
Language:English
Date:28 April 2017
Deposited On:17 Oct 2019 11:10
Last Modified:23 Oct 2019 14:50
Publisher:Wiley-VCH Verlag
ISSN:2509-2383
ISBN:9783527600410
OA Status:Closed
Publisher DOI:https://doi.org/10.1002/3527600418.mb11280kske6017

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