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Calcium oxide [MAK Value Documentation, 2014]


Hartwig, A; MAK Commission; et al; Arand, Michael (2017). Calcium oxide [MAK Value Documentation, 2014]. The MAK Collection for Occupational Health and Safety, 2(3):1119-1121.

Abstract

The German Commission for the Investigation of Health Hazards of Chemical Compounds in the Work Area has derived a maximum concentration at the work place (MAK value) for calcium oxide [1305‐78‐8], considering all toxicity endpoints. The critical effect of calcium oxide is irritation of eyes and upper airways. From studies in volunteers with calcium oxide, a MAK value of 1 mg/m3 for the inhalable fraction is derived. Since local effects are critical, calcium oxide is assigned to Peak Limitation Category I and as there were no irritation effects after 20 minutes exposure to 2 mg/m3, an excursion factor of 2 is set. Studies with calcium oxide show that damage to the embryo or foetus is unlikely when the MAK value is observed and the substance is assigned to Pregnancy Risk Group C. Calcium oxide is neither genotoxic nor carcinogenic. Skin contact is not expected to contribute significantly to systemic toxicity or to lead to sensitization.

Abstract

The German Commission for the Investigation of Health Hazards of Chemical Compounds in the Work Area has derived a maximum concentration at the work place (MAK value) for calcium oxide [1305‐78‐8], considering all toxicity endpoints. The critical effect of calcium oxide is irritation of eyes and upper airways. From studies in volunteers with calcium oxide, a MAK value of 1 mg/m3 for the inhalable fraction is derived. Since local effects are critical, calcium oxide is assigned to Peak Limitation Category I and as there were no irritation effects after 20 minutes exposure to 2 mg/m3, an excursion factor of 2 is set. Studies with calcium oxide show that damage to the embryo or foetus is unlikely when the MAK value is observed and the substance is assigned to Pregnancy Risk Group C. Calcium oxide is neither genotoxic nor carcinogenic. Skin contact is not expected to contribute significantly to systemic toxicity or to lead to sensitization.

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Additional indexing

Item Type:Journal Article, not_refereed, original work
Communities & Collections:04 Faculty of Medicine > Institute of Pharmacology and Toxicology
07 Faculty of Science > Institute of Pharmacology and Toxicology
Dewey Decimal Classification:570 Life sciences; biology
610 Medicine & health
Language:English
Date:26 July 2017
Deposited On:17 Oct 2019 10:38
Last Modified:23 Oct 2019 14:42
Publisher:Wiley-VCH Verlag
ISSN:2509-2383
ISBN:9783527600410
OA Status:Closed
Publisher DOI:https://doi.org/10.1002/3527600418.mb130578e5617

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