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Iodine and inorganic iodides [MAK Value Documentation, 2014]


Hartwig, A; MAK Commission; et al; Arand, Michael (2017). Iodine and inorganic iodides [MAK Value Documentation, 2014]. The MAK Collection for Occupational Health and Safety, 2(2):375-415.

Abstract

The German Commission for the Investigation of Health Hazards of Chemical Compounds in the Work Area has re‐evaluated the maximum concentration at the work place (MAK value) of iodine and inorganic iodides [ 7553‐56‐2], considering all endpoints.The critical effect of iodine and inorganic iodides are disturbances in thyroid function occurring after increased iodine or iodide intake. Because of the long history of iodine deficiency in Germany, there is a high prevalence of subclinical and manifest thyroid gland diseases. An increase in iodine intake is suspected of producing further disturbances in damaged thyroid glands. No MAK value has been established, and iodine remains listed in Section IIb of the List of MAK and BAT Values. This also applies for inorganic iodides. A relationship between the introduction of iodine supplementation and an increase in papillary thyroid tumours in humans cannot be confirmed. Iodine and inorganic iodides are not classified in the categories for Carcinogens or Germ Cell Mutagens. Skin contact may contribute significantly to systemic toxicity and iodine and inorganic iodides are designated with an “H” notation. Sensitization is not expected from the limited data.

Abstract

The German Commission for the Investigation of Health Hazards of Chemical Compounds in the Work Area has re‐evaluated the maximum concentration at the work place (MAK value) of iodine and inorganic iodides [ 7553‐56‐2], considering all endpoints.The critical effect of iodine and inorganic iodides are disturbances in thyroid function occurring after increased iodine or iodide intake. Because of the long history of iodine deficiency in Germany, there is a high prevalence of subclinical and manifest thyroid gland diseases. An increase in iodine intake is suspected of producing further disturbances in damaged thyroid glands. No MAK value has been established, and iodine remains listed in Section IIb of the List of MAK and BAT Values. This also applies for inorganic iodides. A relationship between the introduction of iodine supplementation and an increase in papillary thyroid tumours in humans cannot be confirmed. Iodine and inorganic iodides are not classified in the categories for Carcinogens or Germ Cell Mutagens. Skin contact may contribute significantly to systemic toxicity and iodine and inorganic iodides are designated with an “H” notation. Sensitization is not expected from the limited data.

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Item Type:Journal Article, not_refereed, original work
Communities & Collections:04 Faculty of Medicine > Institute of Pharmacology and Toxicology
07 Faculty of Science > Institute of Pharmacology and Toxicology
Dewey Decimal Classification:570 Life sciences; biology
610 Medicine & health
Language:English
Date:25 April 2017
Deposited On:17 Oct 2019 11:13
Last Modified:23 Oct 2019 14:50
Publisher:Wiley-VCH Verlag
ISSN:2509-2383
ISBN:9783527600410
OA Status:Closed
Publisher DOI:https://doi.org/10.1002/3527600418.mb755356e5717

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