Header

UZH-Logo

Maintenance Infos

tert-Butyl acetate [MAK Value Documentation, 2014]


Hartwig, A; MAK Commission; et al; Arand, Michael (2016). tert-Butyl acetate [MAK Value Documentation, 2014]. The MAK Collection for Occupational Health and Safety, 1(2):578-596.

Abstract

The German Commission for the Investigation of Health Hazards of Chemical Compounds in the Work Area has re‐evaluated the maximum concentration at the workplace (MAK value) of tert‐butyl acetate, considering all toxicity endpoints. Available unpublished study reports and publications are described in detail. The critical effects of tert‐butyl acetate are irritation and systemic effects on the liver and kidneys, in addition neurotoxic effects in rats and mice. The subchronic NOAEC in mice is 100 ml/m3 based on transient acute neurotoxic symptoms which can be used to calculate a MAK value of 50 ml/m3. This value also provides protection from irritation. As the critical effect is systemic, Peak Limitation Category II is assigned. The default excursion factor of 2 is set as no half‐life in blood is known, and it is not clear whether the clinical effects were caused by the substance itself or a metabolite. Damage to the embryo and foetus is unlikely if the MAK value for tert‐butyl acetate is observed taking into consideration the data for the metabolite tert‐butyl alcohol. Therefore tert‐butyl acetate has been classified in Pregnancy Risk Group C. Skin contact is not expected to contribute significantly to systemic toxicity. tert‐Butyl acetate is not genotoxic and carcinogenicity data are missing. Sensitization is not expected from the limited data.

Abstract

The German Commission for the Investigation of Health Hazards of Chemical Compounds in the Work Area has re‐evaluated the maximum concentration at the workplace (MAK value) of tert‐butyl acetate, considering all toxicity endpoints. Available unpublished study reports and publications are described in detail. The critical effects of tert‐butyl acetate are irritation and systemic effects on the liver and kidneys, in addition neurotoxic effects in rats and mice. The subchronic NOAEC in mice is 100 ml/m3 based on transient acute neurotoxic symptoms which can be used to calculate a MAK value of 50 ml/m3. This value also provides protection from irritation. As the critical effect is systemic, Peak Limitation Category II is assigned. The default excursion factor of 2 is set as no half‐life in blood is known, and it is not clear whether the clinical effects were caused by the substance itself or a metabolite. Damage to the embryo and foetus is unlikely if the MAK value for tert‐butyl acetate is observed taking into consideration the data for the metabolite tert‐butyl alcohol. Therefore tert‐butyl acetate has been classified in Pregnancy Risk Group C. Skin contact is not expected to contribute significantly to systemic toxicity. tert‐Butyl acetate is not genotoxic and carcinogenicity data are missing. Sensitization is not expected from the limited data.

Statistics

Citations

Dimensions.ai Metrics

Altmetrics

Additional indexing

Item Type:Journal Article, not_refereed, original work
Communities & Collections:04 Faculty of Medicine > Institute of Pharmacology and Toxicology
07 Faculty of Science > Institute of Pharmacology and Toxicology
Dewey Decimal Classification:570 Life sciences; biology
610 Medicine & health
Language:English
Date:27 April 2016
Deposited On:17 Oct 2019 12:21
Last Modified:17 Oct 2019 12:21
Publisher:Wiley-VCH Verlag
ISSN:2509-2383
ISBN:9783527600410
OA Status:Closed
Publisher DOI:https://doi.org/10.1002/3527600418.mb54088e5716

Download

Full text not available from this repository.
View at publisher

Get full-text in a library