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Dimethyl sulfoxide [MAK Value Documentation, 2017]


Hartwig, A; MAK Commission; et al; Arand, Michael (2017). Dimethyl sulfoxide [MAK Value Documentation, 2017]. The MAK Collection for Occupational Health and Safety, 2(4):1548-1550.

Abstract

The German Commission for the Investigation of Health Hazards of Chemical Compounds in the Work Area has evaluated the possibility to add the indication “Prerequisite for Pregnancy Risk Group C” to the classification of Pregnancy Risk Group B for dimethyl sulfoxide [67‐68‐5] at the maximum concentration at the workplace (MAK value) of 50 ml/m3. The lowest NOAEL for developmental toxicity in rabbits is 300 mg/kg body weight/day, which after toxicokinetic scaling corresponds to a concentration of 268 ml/m3 at the workplace. Liquid dimethyl sulfoxide penetrates the skin at the same rate as dimethylformamide. In addition to the amount taken up via the lung, it has to be assumed that the same amount of dimethyl sulfoxide is taken up via the skin from the gas phase as was shown with dimethylformamide in volunteers. Therefore, damage to the embryo or foetus is unlikely at the concentration of 12 l/m3 and less. An exposure to this concentration would be the prerequisite for an assignment to Pregnancy Risk Group C.

Abstract

The German Commission for the Investigation of Health Hazards of Chemical Compounds in the Work Area has evaluated the possibility to add the indication “Prerequisite for Pregnancy Risk Group C” to the classification of Pregnancy Risk Group B for dimethyl sulfoxide [67‐68‐5] at the maximum concentration at the workplace (MAK value) of 50 ml/m3. The lowest NOAEL for developmental toxicity in rabbits is 300 mg/kg body weight/day, which after toxicokinetic scaling corresponds to a concentration of 268 ml/m3 at the workplace. Liquid dimethyl sulfoxide penetrates the skin at the same rate as dimethylformamide. In addition to the amount taken up via the lung, it has to be assumed that the same amount of dimethyl sulfoxide is taken up via the skin from the gas phase as was shown with dimethylformamide in volunteers. Therefore, damage to the embryo or foetus is unlikely at the concentration of 12 l/m3 and less. An exposure to this concentration would be the prerequisite for an assignment to Pregnancy Risk Group C.

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Item Type:Journal Article, not_refereed, original work
Communities & Collections:04 Faculty of Medicine > Institute of Pharmacology and Toxicology
07 Faculty of Science > Institute of Pharmacology and Toxicology
Dewey Decimal Classification:570 Life sciences; biology
610 Medicine & health
Language:English
Date:27 October 2017
Deposited On:17 Oct 2019 12:20
Last Modified:23 Oct 2019 14:39
Publisher:Wiley-VCH Verlag
ISSN:2509-2383
ISBN:9783527600410
OA Status:Closed
Publisher DOI:https://doi.org/10.1002/3527600418.mb6768e6217

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