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2-Ethylhexyl acetate [MAK Value Documentation, 2014]


Hartwig, A; MAK Commission; et al; Arand, Michael (2017). 2-Ethylhexyl acetate [MAK Value Documentation, 2014]. The MAK Collection for Occupational Health and Safety, 2(1):21-33.

Abstract

The German Commission for the Investigation of Health Hazards of Chemical Compounds in the Work Area has evaluated 2‐ethylhexyl acetate to derive a maximum concentration at the workplace (MAK value), considering all toxicological endpoints examined. Available publications and unpublished study reports are described in detail. 2‐Ethylhexyl acetate is rapidly hydrolysed to 2‐ethylhexanol and acetic acid. Local irritation is the critical effect of 2‐ethylhexanol and acetic acid, and the same is assumed for 2‐ethylhexyl acetate. Studies with repeated inhalation exposure or oral administration to 2‐ethylhexyl acetate are not available. By analogy with its metabolites 2‐ethylhexanol and acetic acid, a MAK value of 10 ml/m3 has therefore been established for 2‐ethylhexyl acetate. 2‐Ethylhexyl acetate has been classified by analogy with 2‐ethylhexanol in Peak Limitation Category I with an excursion factor of 1. 2‐Ethylhexyl acetate is not expected to have genotoxic effects. The metabolite 2‐ethylhexanol caused liver tumours in a long‐term study with oral administration only at clearly toxic doses of 750 mg/kg body weight and day and only in female mice. If the MAK value, which protects against liver toxicity, is observed, liver tumours are not expected. Skin absorption does not contribute to systemic toxicity. In studies with humans, 2‐ethylhexyl acetate did not cause sensitization of the skin; there are no studies with animals available. Damage to the embryo or foetus is unlikely when the MAK value is not exceeded.

Abstract

The German Commission for the Investigation of Health Hazards of Chemical Compounds in the Work Area has evaluated 2‐ethylhexyl acetate to derive a maximum concentration at the workplace (MAK value), considering all toxicological endpoints examined. Available publications and unpublished study reports are described in detail. 2‐Ethylhexyl acetate is rapidly hydrolysed to 2‐ethylhexanol and acetic acid. Local irritation is the critical effect of 2‐ethylhexanol and acetic acid, and the same is assumed for 2‐ethylhexyl acetate. Studies with repeated inhalation exposure or oral administration to 2‐ethylhexyl acetate are not available. By analogy with its metabolites 2‐ethylhexanol and acetic acid, a MAK value of 10 ml/m3 has therefore been established for 2‐ethylhexyl acetate. 2‐Ethylhexyl acetate has been classified by analogy with 2‐ethylhexanol in Peak Limitation Category I with an excursion factor of 1. 2‐Ethylhexyl acetate is not expected to have genotoxic effects. The metabolite 2‐ethylhexanol caused liver tumours in a long‐term study with oral administration only at clearly toxic doses of 750 mg/kg body weight and day and only in female mice. If the MAK value, which protects against liver toxicity, is observed, liver tumours are not expected. Skin absorption does not contribute to systemic toxicity. In studies with humans, 2‐ethylhexyl acetate did not cause sensitization of the skin; there are no studies with animals available. Damage to the embryo or foetus is unlikely when the MAK value is not exceeded.

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Additional indexing

Item Type:Journal Article, not_refereed, original work
Communities & Collections:04 Faculty of Medicine > Institute of Pharmacology and Toxicology
07 Faculty of Science > Institute of Pharmacology and Toxicology
Dewey Decimal Classification:570 Life sciences; biology
610 Medicine & health
Language:English
Date:26 January 2017
Deposited On:17 Oct 2019 12:45
Last Modified:24 Oct 2019 06:42
Publisher:Wiley-VCH Verlag
ISSN:2509-2383
ISBN:9783527600410
OA Status:Closed
Publisher DOI:https://doi.org/10.1002/3527600418.mb10309e5617

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