Header

UZH-Logo

Maintenance Infos

n-Butyl alcohol [MAK Value Documentation, 2015]


Hartwig, A; MAK Commission; et al; Arand, Michael (2016). n-Butyl alcohol [MAK Value Documentation, 2015]. The MAK Collection for Occupational Health and Safety, 1(2):597-599.

Abstract

The German Commission for the Investigation of Health Hazards of Chemical Compounds in the Work Area has re‐evaluated the data on skin absorption of n‐butyl alcohol. n‐Butyl alcohol was previously not designated with an “H” notation. Skin absorption data from animal studies in vivo and from human skin in vitro are conflicting, showing much higher penetration rates in vivo than in vitro. A new in vivo study with the isomeric tert‐butyl alcohol shows a rather low degree of skin absorption. Taking these data as a read‐across, the lower penetration rates of n‐butyl alcohol with human skin in vitro are plausible. n‐Butyl alcohol continues not to be designated with an “H” notation because skin absorption is not expected to contribute to systemic toxicity.

Abstract

The German Commission for the Investigation of Health Hazards of Chemical Compounds in the Work Area has re‐evaluated the data on skin absorption of n‐butyl alcohol. n‐Butyl alcohol was previously not designated with an “H” notation. Skin absorption data from animal studies in vivo and from human skin in vitro are conflicting, showing much higher penetration rates in vivo than in vitro. A new in vivo study with the isomeric tert‐butyl alcohol shows a rather low degree of skin absorption. Taking these data as a read‐across, the lower penetration rates of n‐butyl alcohol with human skin in vitro are plausible. n‐Butyl alcohol continues not to be designated with an “H” notation because skin absorption is not expected to contribute to systemic toxicity.

Statistics

Citations

Dimensions.ai Metrics

Altmetrics

Additional indexing

Item Type:Journal Article, not_refereed, original work
Communities & Collections:04 Faculty of Medicine > Institute of Pharmacology and Toxicology
07 Faculty of Science > Institute of Pharmacology and Toxicology
Dewey Decimal Classification:570 Life sciences; biology
610 Medicine & health
Language:English
Date:27 April 2016
Deposited On:17 Oct 2019 12:43
Last Modified:17 Oct 2019 12:43
Publisher:Wiley-VCH Verlag
ISSN:2509-2383
ISBN:9783527600410
OA Status:Closed
Publisher DOI:https://doi.org/10.1002/3527600418.mb7136e5816

Download

Full text not available from this repository.
View at publisher

Get full-text in a library