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Dimethyl sulfoxide (DMSO) [MAK Value Documentation, 2011]


Hartwig, A; MAK Commission; et al; Arand, Michael (2017). Dimethyl sulfoxide (DMSO) [MAK Value Documentation, 2011]. The MAK Collection for Occupational Health and Safety, 2(3):1135-1137.

Abstract

The German Commission for the Investigation of Health Hazards of Chemical Compounds in the Work Area has re‐evaluated the designation with “H” (for substances for which skin contact is expected to contribute significantly to the systemic toxicity) for DMSO [67‐68‐5]. Based on a diffusion cell study with excised human skin, 35.2 g DMSO (about 500 mg/kg body weight) would be dermally absorbed each hour through an area of 2000 cm2 of skin. This amount corresponds to about half of the LOAEL (lowest observed adverse effect level) established in volunteers. Therefore, skin contact is expected to contribute significantly to the systemic toxicity of DMSO, and DMSO is still designated with an “H”.

Abstract

The German Commission for the Investigation of Health Hazards of Chemical Compounds in the Work Area has re‐evaluated the designation with “H” (for substances for which skin contact is expected to contribute significantly to the systemic toxicity) for DMSO [67‐68‐5]. Based on a diffusion cell study with excised human skin, 35.2 g DMSO (about 500 mg/kg body weight) would be dermally absorbed each hour through an area of 2000 cm2 of skin. This amount corresponds to about half of the LOAEL (lowest observed adverse effect level) established in volunteers. Therefore, skin contact is expected to contribute significantly to the systemic toxicity of DMSO, and DMSO is still designated with an “H”.

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Item Type:Journal Article, not_refereed, original work
Communities & Collections:04 Faculty of Medicine > Institute of Pharmacology and Toxicology
07 Faculty of Science > Institute of Pharmacology and Toxicology
Dewey Decimal Classification:570 Life sciences; biology
610 Medicine & health
Language:English
Date:26 July 2017
Deposited On:17 Oct 2019 12:36
Last Modified:17 Oct 2019 12:39
Publisher:Wiley-VCH Verlag
ISSN:2509-2383
ISBN:9783527600410
OA Status:Closed
Publisher DOI:https://doi.org/10.1002/3527600418.mb6768e5117

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