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Di(2-ethylhexyl) phthalate (DEHP) [MAK Value Documentation, 2016]


Hartwig, A; MAK Commission; et al; Arand, Michael (2017). Di(2-ethylhexyl) phthalate (DEHP) [MAK Value Documentation, 2016]. The MAK Collection for Occupational Health and Safety, 2(2):284-336.

Abstract

The German Commission for the Investigation of Health Hazards of Chemical Compounds in the Work Area has re‐evaluated the developmental toxicity of di(2‐ethylhexyl) phthalate (DEHP) [117‐81‐7]. In 2014, the maximum concentration at the work place (MAK value) of DEHP has been set to 2 mgm for the inhalable fraction.
In some studies, a correlation between prenatal DEHP exposure and effects on anogenital distance of male newborns, birth weight and pregnancy duration in humans are found, however, the results are not consistent.
Teratogenicity is observed in rats only at maternally toxic doses of 1000 mg/kg bw and day and above, in mice at 91 mg/kg bw and day. NOAELs for teratogenicity are 200 mg/kg bw and day for rats and 44 mg/kg body weight and day for mice, the latter corresponding to 29 mg/m3 after scaling to a concentration at the work place. In contrast to mouse and marmoset the rat is very sensitive to DEHP effects on the male reproductive organs. From a three generation study the Commission deduces a NOAEL for pre‐ and postnatal developmental toxicity to the male reproductive organs and for fetotoxicity of 46 mg/kg bw and day for rats, corresponding to 54 mg/m3after scaling to a concentration at the work place. The reported effects, small testes, reduced absolute weights of testis and epididymis, are considered by the Commission as not being adverse because they do not show correlating consequences for the next generation or dose‐response relationship and changes in relative organ weights and histopathological correlates are not observed. After in utero exposure, germ cell organization, mRNA expression and protein level of StAR („steroidogenic acute regulatory protein“) in testes are affected at 100 mg/kg bw and day and above. These effects resulted in a NOAEL for prenatal developmental effects of the male reproductive organs of 30 mg/kg bw and day for rats, corresponding to 35 mg/m3. For mice in prenatal developmental studies a NOAEL for fetotoxicity as well as prenatal developmental toxicity of 48 mg/kg bw and day is derived, corresponding to 32 mg/m3. Damage to the embryo or foetus is unlikely when the MAK value is observed and DEHP is classified in Pregnancy Risk Group C.

Abstract

The German Commission for the Investigation of Health Hazards of Chemical Compounds in the Work Area has re‐evaluated the developmental toxicity of di(2‐ethylhexyl) phthalate (DEHP) [117‐81‐7]. In 2014, the maximum concentration at the work place (MAK value) of DEHP has been set to 2 mgm for the inhalable fraction.
In some studies, a correlation between prenatal DEHP exposure and effects on anogenital distance of male newborns, birth weight and pregnancy duration in humans are found, however, the results are not consistent.
Teratogenicity is observed in rats only at maternally toxic doses of 1000 mg/kg bw and day and above, in mice at 91 mg/kg bw and day. NOAELs for teratogenicity are 200 mg/kg bw and day for rats and 44 mg/kg body weight and day for mice, the latter corresponding to 29 mg/m3 after scaling to a concentration at the work place. In contrast to mouse and marmoset the rat is very sensitive to DEHP effects on the male reproductive organs. From a three generation study the Commission deduces a NOAEL for pre‐ and postnatal developmental toxicity to the male reproductive organs and for fetotoxicity of 46 mg/kg bw and day for rats, corresponding to 54 mg/m3after scaling to a concentration at the work place. The reported effects, small testes, reduced absolute weights of testis and epididymis, are considered by the Commission as not being adverse because they do not show correlating consequences for the next generation or dose‐response relationship and changes in relative organ weights and histopathological correlates are not observed. After in utero exposure, germ cell organization, mRNA expression and protein level of StAR („steroidogenic acute regulatory protein“) in testes are affected at 100 mg/kg bw and day and above. These effects resulted in a NOAEL for prenatal developmental effects of the male reproductive organs of 30 mg/kg bw and day for rats, corresponding to 35 mg/m3. For mice in prenatal developmental studies a NOAEL for fetotoxicity as well as prenatal developmental toxicity of 48 mg/kg bw and day is derived, corresponding to 32 mg/m3. Damage to the embryo or foetus is unlikely when the MAK value is observed and DEHP is classified in Pregnancy Risk Group C.

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Item Type:Journal Article, not_refereed, original work
Communities & Collections:04 Faculty of Medicine > Institute of Pharmacology and Toxicology
07 Faculty of Science > Institute of Pharmacology and Toxicology
Dewey Decimal Classification:570 Life sciences; biology
610 Medicine & health
Language:English
Date:28 April 2017
Deposited On:17 Oct 2019 12:38
Last Modified:17 Oct 2019 12:39
Publisher:Wiley-VCH Verlag
ISSN:2509-2383
ISBN:9783527600410
OA Status:Closed
Publisher DOI:https://doi.org/10.1002/3527600418.mb11781e6017

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