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N,N-Dimethylethylamine [MAK Value Documentations, 2000]


Hartwig, A; MAK Commission; et al; Arand, Michael (2016). N,N-Dimethylethylamine [MAK Value Documentations, 2000]. The MAK Collection for Occupational Health and Safety:online.

Abstract

N,N‐dimethylethylamine is rapidly absorbed orally or by inhalation, but only to a slight extent through the skin. It is rapidly distributed, and 90% is converted into N,N‐dimethylethylamine oxide via N‐oxidation. In humans, the half‐live in plasma is 1.5 hours for N,N‐dimethylethylamine and 3 hours for the N‐oxide. Elimination with the urine takes place in 2 phases, with a half‐live of 1.5 and 7 hours for N,N‐dimethylethylamine and 2.5 and 8 hours for the N‐oxide. A good correlation exists between exposure and the N,N‐dimethylethylamine concentration in plasma or urine. In animal experiments, liquid N,N‐dimethylethylamine is corrosive to skin and eyes.

Abstract

N,N‐dimethylethylamine is rapidly absorbed orally or by inhalation, but only to a slight extent through the skin. It is rapidly distributed, and 90% is converted into N,N‐dimethylethylamine oxide via N‐oxidation. In humans, the half‐live in plasma is 1.5 hours for N,N‐dimethylethylamine and 3 hours for the N‐oxide. Elimination with the urine takes place in 2 phases, with a half‐live of 1.5 and 7 hours for N,N‐dimethylethylamine and 2.5 and 8 hours for the N‐oxide. A good correlation exists between exposure and the N,N‐dimethylethylamine concentration in plasma or urine. In animal experiments, liquid N,N‐dimethylethylamine is corrosive to skin and eyes.

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Additional indexing

Item Type:Journal Article, not_refereed, original work
Communities & Collections:04 Faculty of Medicine > Institute of Pharmacology and Toxicology
07 Faculty of Science > Institute of Pharmacology and Toxicology
Dewey Decimal Classification:570 Life sciences; biology
610 Medicine & health
Language:English
Date:13 April 2016
Deposited On:17 Oct 2019 12:29
Last Modified:17 Oct 2019 12:31
Publisher:Wiley-VCH Verlag
ISSN:2509-2383
ISBN:9783527600410
OA Status:Closed
Publisher DOI:https://doi.org/10.1002/3527600418.mb59856e3016

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