Abstract
N,N‐dimethylethylamine is rapidly absorbed orally or by inhalation, but only to a slight extent through the skin. It is rapidly distributed, and 90% is converted into N,N‐dimethylethylamine oxide via N‐oxidation. In humans, the half‐live in plasma is 1.5 hours for N,N‐dimethylethylamine and 3 hours for the N‐oxide. Elimination with the urine takes place in 2 phases, with a half‐live of 1.5 and 7 hours for N,N‐dimethylethylamine and 2.5 and 8 hours for the N‐oxide. A good correlation exists between exposure and the N,N‐dimethylethylamine concentration in plasma or urine. In animal experiments, liquid N,N‐dimethylethylamine is corrosive to skin and eyes.
Hartwig, A