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Methoxyessigsäure [MAK Value Documentation in German language, 2016]


Hartwig, A; MAK Commission; et al; Arand, Michael (2016). Methoxyessigsäure [MAK Value Documentation in German language, 2016]. The MAK Collection for Occupational Health and Safety, 1(2):1053-1055.

Abstract

Methoxyacetic acid
The German Commission for the Investigation of Health Hazards of Chemical Compounds in the Work Area has re‐evaluated the maximum concentration at the workplace (MAK value) of 1 ml/m3 for methoxyacetic acid, considering the endpoints local and systemic toxicity as well as developmental toxicity. Methoxyacetic acid acts locally as well as systemically. It is the metabolite responsible for the haematotoxicity and reproductive toxicity of the better investigated methoxyethanol. Hence, the MAK value of 1 ml methoxyethanol/m3 was also assigned to methoxyacetic acid in 2008. A 28‐day study with rats shows a NOAEC for systemic and local effects of 15 ml/m3. Since 2014, the Commission uses an empirical approach to set MAK values for substances with critical effects on the upper respiratory tract or the eyes. According to this approach, a concentration of 0.9 ml/m3 for the workplace air can be calculated from this study. Therefore, the MAK value of 1 ml/m3 is confirmed. Systemic as well as local effects are critical and the assignment to Peak Limitation Category II for systemic effects is retained. However, to avoid sensory irritation, the former excursion factor of 8 seems too high and is reduced to 2 in analogy to the excursion factors for formic and acetic acid. The assignment to Pregnancy Risk Group B, substances for which damage to the embryo or foetus cannot be excluded even when the MAK value is observed, is confirmed.

Abstract

Methoxyacetic acid
The German Commission for the Investigation of Health Hazards of Chemical Compounds in the Work Area has re‐evaluated the maximum concentration at the workplace (MAK value) of 1 ml/m3 for methoxyacetic acid, considering the endpoints local and systemic toxicity as well as developmental toxicity. Methoxyacetic acid acts locally as well as systemically. It is the metabolite responsible for the haematotoxicity and reproductive toxicity of the better investigated methoxyethanol. Hence, the MAK value of 1 ml methoxyethanol/m3 was also assigned to methoxyacetic acid in 2008. A 28‐day study with rats shows a NOAEC for systemic and local effects of 15 ml/m3. Since 2014, the Commission uses an empirical approach to set MAK values for substances with critical effects on the upper respiratory tract or the eyes. According to this approach, a concentration of 0.9 ml/m3 for the workplace air can be calculated from this study. Therefore, the MAK value of 1 ml/m3 is confirmed. Systemic as well as local effects are critical and the assignment to Peak Limitation Category II for systemic effects is retained. However, to avoid sensory irritation, the former excursion factor of 8 seems too high and is reduced to 2 in analogy to the excursion factors for formic and acetic acid. The assignment to Pregnancy Risk Group B, substances for which damage to the embryo or foetus cannot be excluded even when the MAK value is observed, is confirmed.

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Additional indexing

Item Type:Journal Article, not_refereed, original work
Communities & Collections:04 Faculty of Medicine > Institute of Pharmacology and Toxicology
07 Faculty of Science > Institute of Pharmacology and Toxicology
Dewey Decimal Classification:570 Life sciences; biology
610 Medicine & health
Language:German
Date:27 April 2016
Deposited On:18 Oct 2019 08:54
Last Modified:18 Oct 2019 08:56
Publisher:Wiley-VCH Verlag
ISSN:2509-2383
ISBN:9783527600410
OA Status:Closed
Publisher DOI:https://doi.org/10.1002/3527600418.mb62545d0060

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