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Phosphorylchlorid [MAK Value Documentation in German language, 2016]


Kreis, P; Bartsch, R; van Thriel, C; Brüning, T; Hartwig, A; MAK Commission; et al; Arand, Michael (2016). Phosphorylchlorid [MAK Value Documentation in German language, 2016]. The MAK Collection for Occupational Health and Safety, 1(1):252-255.

Abstract

MAK Value Documentation for Phosphorus oxychloride

The German Commission for the Investigation of Health Hazards of Chemical Compounds in the Work Area has re‐evaluated the maximum concentration at the work place (MAK value) of phosphorus oxychloride of 0.2 ml/m3, considering the endpoints local and systemic toxicity as well as developmental toxicity. Available publications are described in detail. Phosphorus oxychloride is corrosive to eyes and skin and hydrolyses in water to hydrogen chloride and phosphoric acid, similar to phosphorus trichloride. There is not enough data for phosphorus oxychloride to set a MAK value because valid inhalation studies with repeated exposure are missing. Therefore, the MAK value of phosphorus oxychloride is derived by using a read‐across to phosphorus trichloride for which a MAK value of 0.1 ml/m3 has been set based on a 28‐day inhalation study. Considering the fivefold higher NOAEC of phosphorus trichloride for sensory irritation in volunteers and rats the MAK value for phosphorus oxychloride is lowered accordingly to 0.02 ml/m3. The assignment to Peak Limitation Category I, because local effects are critical, and the excursion factor of 1 are confirmed. The assignment to Pregnancy Risk Group C is retained as damage to the embryo or foetus is unlikely when the MAK value is observed.

Abstract

MAK Value Documentation for Phosphorus oxychloride

The German Commission for the Investigation of Health Hazards of Chemical Compounds in the Work Area has re‐evaluated the maximum concentration at the work place (MAK value) of phosphorus oxychloride of 0.2 ml/m3, considering the endpoints local and systemic toxicity as well as developmental toxicity. Available publications are described in detail. Phosphorus oxychloride is corrosive to eyes and skin and hydrolyses in water to hydrogen chloride and phosphoric acid, similar to phosphorus trichloride. There is not enough data for phosphorus oxychloride to set a MAK value because valid inhalation studies with repeated exposure are missing. Therefore, the MAK value of phosphorus oxychloride is derived by using a read‐across to phosphorus trichloride for which a MAK value of 0.1 ml/m3 has been set based on a 28‐day inhalation study. Considering the fivefold higher NOAEC of phosphorus trichloride for sensory irritation in volunteers and rats the MAK value for phosphorus oxychloride is lowered accordingly to 0.02 ml/m3. The assignment to Peak Limitation Category I, because local effects are critical, and the excursion factor of 1 are confirmed. The assignment to Pregnancy Risk Group C is retained as damage to the embryo or foetus is unlikely when the MAK value is observed.

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Item Type:Journal Article, not_refereed, original work
Communities & Collections:04 Faculty of Medicine > Institute of Pharmacology and Toxicology
07 Faculty of Science > Institute of Pharmacology and Toxicology
Dewey Decimal Classification:570 Life sciences; biology
610 Medicine & health
Language:German
Date:28 January 2016
Deposited On:18 Oct 2019 09:02
Last Modified:18 Oct 2019 09:02
Publisher:Wiley-VCH Verlag
ISSN:2509-2383
ISBN:9783527600410
OA Status:Closed
Publisher DOI:https://doi.org/10.1002/3527600418.mb1002587d0060

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