Header

UZH-Logo

Maintenance Infos

Adipinsäure [MAK Value Documentation in German language, 2017]


Hartwig, Andrea; MAK Commission; et al; Arand, Michael (2017). Adipinsäure [MAK Value Documentation in German language, 2017]. The MAK Collection for Occupational Health and Safety, 2(1):41-58.

Abstract

The German Commission for the Investigation of Health Hazards of Chemical Compounds in the Work Area has evaluated adipic acid to derive a maximum concentration at the workplace (MAK value), considering all toxicity endpoints.

The critical effect is moderate local irritation as shown with the Draize test in the rabbit eye. Available inhalation studies are limited and not suitable to derive a MAK value. Systemic toxicity only occurs at high doses. In a limited oral 2‐year study the body weight of rats was reduced at 2250 mg/kg body weight/day. The resulting systemic NOAEL is 750 mg/kg body weight/day.

After comparing adipic acid with other solid acids, a MAK value of 2 mg adipic acid/m3 I has been set in analogy to phosphoric acid, which is considered to be the worst‐case.

As the critical effect is local, adipic acid is assigned to Peak Limitation Category I. In analogy to phosphoric acid, a default excursion factor of 2 is set.

There is no reason to fear damage to the embryo or foetus when the MAK value is observed; thus, the substance is classified in Pregnancy Risk Group C.

Adipic acid is not genotoxic and not carcinogenic. No contact sensitizing effects have been observed. Skin contact is not expected to contribute significantly to systemic toxicity.

Abstract

The German Commission for the Investigation of Health Hazards of Chemical Compounds in the Work Area has evaluated adipic acid to derive a maximum concentration at the workplace (MAK value), considering all toxicity endpoints.

The critical effect is moderate local irritation as shown with the Draize test in the rabbit eye. Available inhalation studies are limited and not suitable to derive a MAK value. Systemic toxicity only occurs at high doses. In a limited oral 2‐year study the body weight of rats was reduced at 2250 mg/kg body weight/day. The resulting systemic NOAEL is 750 mg/kg body weight/day.

After comparing adipic acid with other solid acids, a MAK value of 2 mg adipic acid/m3 I has been set in analogy to phosphoric acid, which is considered to be the worst‐case.

As the critical effect is local, adipic acid is assigned to Peak Limitation Category I. In analogy to phosphoric acid, a default excursion factor of 2 is set.

There is no reason to fear damage to the embryo or foetus when the MAK value is observed; thus, the substance is classified in Pregnancy Risk Group C.

Adipic acid is not genotoxic and not carcinogenic. No contact sensitizing effects have been observed. Skin contact is not expected to contribute significantly to systemic toxicity.

Statistics

Citations

Dimensions.ai Metrics

Altmetrics

Additional indexing

Item Type:Journal Article, not_refereed, original work
Communities & Collections:04 Faculty of Medicine > Institute of Pharmacology and Toxicology
07 Faculty of Science > Institute of Pharmacology and Toxicology
Dewey Decimal Classification:570 Life sciences; biology
610 Medicine & health
Language:German
Date:26 January 2017
Deposited On:18 Oct 2019 08:13
Last Modified:18 Oct 2019 08:14
Publisher:Wiley-VCH Verlag
ISSN:2509-2383
ISBN:9783527600410
OA Status:Closed
Publisher DOI:https://doi.org/10.1002/3527600418.mb12404kskd0062

Download

Full text not available from this repository.
View at publisher

Get full-text in a library