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N-Isopropyl-N′-phenyl-p-phenylenediamine [MAK Value Documentation, 2011]


Hartwig, A; MAK Commission; et al; Arand, Michael (2016). N-Isopropyl-N′-phenyl-p-phenylenediamine [MAK Value Documentation, 2011]. The MAK Collection for Occupational Health and Safety, 1(2):771-779.

Abstract

N‐Isopropyl‐N′‐phenyl‐p‐phenylenediamine is used mainly as a stabilizer (antioxidant) in the rubber industry. The main field of application is the tyre manufacturing sector. In addition, antiozonization agents such as N‐isopropyl‐N′‐phenyl‐p‐phenylenediamine are found also in other rubber products. N‐isopropyl‐N′‐phenyl‐p‐phenylenediamine is non irritating to the skin. The skin‐sensitizing effects of N‐isopropyl‐N′‐phenyl‐p‐phenylenediamine are sufficiently documented, both as a result of clinical observations in humans and the findings in animal studies. N‐Isopropyl‐N′‐phenyl‐p‐phenylenediamine is therefore given the designation “Sh” (for substances which cause sensitization of the skin). As there are no data available for sensitizing effects on the airways, the substance is not designated with “Sa”.

Abstract

N‐Isopropyl‐N′‐phenyl‐p‐phenylenediamine is used mainly as a stabilizer (antioxidant) in the rubber industry. The main field of application is the tyre manufacturing sector. In addition, antiozonization agents such as N‐isopropyl‐N′‐phenyl‐p‐phenylenediamine are found also in other rubber products. N‐isopropyl‐N′‐phenyl‐p‐phenylenediamine is non irritating to the skin. The skin‐sensitizing effects of N‐isopropyl‐N′‐phenyl‐p‐phenylenediamine are sufficiently documented, both as a result of clinical observations in humans and the findings in animal studies. N‐Isopropyl‐N′‐phenyl‐p‐phenylenediamine is therefore given the designation “Sh” (for substances which cause sensitization of the skin). As there are no data available for sensitizing effects on the airways, the substance is not designated with “Sa”.

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Item Type:Journal Article, not_refereed, original work
Communities & Collections:04 Faculty of Medicine > Institute of Pharmacology and Toxicology
07 Faculty of Science > Institute of Pharmacology and Toxicology
Dewey Decimal Classification:570 Life sciences; biology
610 Medicine & health
Language:English
Date:27 April 2016
Deposited On:18 Oct 2019 08:56
Last Modified:18 Oct 2019 08:56
Publisher:Wiley-VCH Verlag
ISSN:2509-2383
ISBN:9783527600410
OA Status:Closed
Publisher DOI:https://doi.org/10.1002/3527600418.mb10172e5116

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