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Di-n-butylphosphonat und Di-n-octylphosphonat [MAK Value Documentation in German language, 2016]


Hartwig, A; MAK Commission; et al; Arand, Michael (2016). Di-n-butylphosphonat und Di-n-octylphosphonat [MAK Value Documentation in German language, 2016]. The MAK Collection for Occupational Health and Safety, 1(2):917-926.

Abstract

The German Commission for the Investigation of Health Hazards of Chemical Compounds in the Work Area has evaluated di‐n‐butyl phosphonate and di‐n‐octyl phosphonate to derive a maximum concentration at the workplace (MAK value), considering all toxicity endpoints. Unpublished study reports and publications are described in detail. In vitro genotoxicity tests are negative; in vivo data are not available. Critical effect for both substances is irritation of skin or eyes. No repeated dose studies are available to define possible local and systemic effects. Therefore, no MAK value can be established and di‐n‐butyl phosphonate and di‐n‐octyl phosphonate are assigned to Section II b of the List of MAK and BAT values. Skin contact is not expected to contribute significantly to systemic toxicity. A maximization test with di‐n‐octyl phosphonate and an in vitro test with di‐n‐butyl phosphonate do not show sensitizing activity.

Abstract

The German Commission for the Investigation of Health Hazards of Chemical Compounds in the Work Area has evaluated di‐n‐butyl phosphonate and di‐n‐octyl phosphonate to derive a maximum concentration at the workplace (MAK value), considering all toxicity endpoints. Unpublished study reports and publications are described in detail. In vitro genotoxicity tests are negative; in vivo data are not available. Critical effect for both substances is irritation of skin or eyes. No repeated dose studies are available to define possible local and systemic effects. Therefore, no MAK value can be established and di‐n‐butyl phosphonate and di‐n‐octyl phosphonate are assigned to Section II b of the List of MAK and BAT values. Skin contact is not expected to contribute significantly to systemic toxicity. A maximization test with di‐n‐octyl phosphonate and an in vitro test with di‐n‐butyl phosphonate do not show sensitizing activity.

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Additional indexing

Item Type:Journal Article, not_refereed, original work
Communities & Collections:04 Faculty of Medicine > Institute of Pharmacology and Toxicology
07 Faculty of Science > Institute of Pharmacology and Toxicology
Dewey Decimal Classification:570 Life sciences; biology
610 Medicine & health
Language:German
Date:27 April 2016
Deposited On:17 Oct 2019 13:12
Last Modified:17 Oct 2019 13:12
Publisher:Wiley-VCH Verlag
ISSN:2509-2383
ISBN:9783527600410
OA Status:Closed
Publisher DOI:https://doi.org/10.1002/3527600418.mb180919d0060

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