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N,N-Dimethylformamid [MAK Value Documentation in German language, 2017]


Hartwig, Andrea; MAK Commission; et al; Arand, Michael (2017). N,N-Dimethylformamid [MAK Value Documentation in German language, 2017]. The MAK Collection for Occupational Health and Safety, 2(1):122-123.

Abstract

he German Commission for the Investigation of Health Hazards of Chemical Compounds in the Work Area has evaluated the possibility to add the indication "prerequisite for Pregnancy Risk Group C” to the classification of Pregnancy Risk Group B for dimethylformamide at the maximum concentration at the workplace (MAK value) of 5 ml/m3. The NOAECs for developmental toxicity are 31 ml/m3 in rats and 50 ml/m3 in rabbits. Only a LOAEL is available for mice. From this LOAEL of 182 mg/kg body weight/day, which after toxicokinetic scaling corresponds to a concentration of 67 ml/m3 at the workplace, the Commission estimated a NAEC of 22 ml/m3.
After whole body exposure of volunteers to dimethylformamide, the same amount was found to be taken up from the gas phase via the lung as via the skin. Therefore, damage to the embryo or foetus is unlikely at the concentration of 1 ml/m3 and less. An exposure not higher than this concentration would be the prerequisite for an assignment to Pregnancy Risk Group C.

Abstract

he German Commission for the Investigation of Health Hazards of Chemical Compounds in the Work Area has evaluated the possibility to add the indication "prerequisite for Pregnancy Risk Group C” to the classification of Pregnancy Risk Group B for dimethylformamide at the maximum concentration at the workplace (MAK value) of 5 ml/m3. The NOAECs for developmental toxicity are 31 ml/m3 in rats and 50 ml/m3 in rabbits. Only a LOAEL is available for mice. From this LOAEL of 182 mg/kg body weight/day, which after toxicokinetic scaling corresponds to a concentration of 67 ml/m3 at the workplace, the Commission estimated a NAEC of 22 ml/m3.
After whole body exposure of volunteers to dimethylformamide, the same amount was found to be taken up from the gas phase via the lung as via the skin. Therefore, damage to the embryo or foetus is unlikely at the concentration of 1 ml/m3 and less. An exposure not higher than this concentration would be the prerequisite for an assignment to Pregnancy Risk Group C.

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Item Type:Journal Article, not_refereed, original work
Communities & Collections:04 Faculty of Medicine > Institute of Pharmacology and Toxicology
07 Faculty of Science > Institute of Pharmacology and Toxicology
Dewey Decimal Classification:570 Life sciences; biology
610 Medicine & health
Language:German
Date:26 January 2017
Deposited On:17 Oct 2019 13:08
Last Modified:17 Oct 2019 13:09
Publisher:Wiley-VCH Verlag
ISSN:2509-2383
ISBN:9783527600410
OA Status:Closed
Publisher DOI:https://doi.org/10.1002/3527600418.mb6812d0062

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