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Alkylamine, C11-14-verzweigte, Monohexyl- und Dihexylphosphate [MAK Value Documentation in German language, 2017]


Hartwig, Andrea; MAK Commission; et al; Arand, Michael (2017). Alkylamine, C11-14-verzweigte, Monohexyl- und Dihexylphosphate [MAK Value Documentation in German language, 2017]. The MAK Collection for Occupational Health and Safety, 2(1):59-65.

Abstract

The German Commission for the Investigation of Health Hazards of Chemical Compounds in the Work Area has evaluated alkyl amines, C11‐14‐branched, monohexyl and dihexyl phosphates to derive a maximum concentration at the workplace (MAK value), considering all toxicity endpoints. In a screening study according to OECD Test Guideline 422, inflammation in the lymph nodes and the adrenals was seen at the lowest dose of 10 mg/kg body weight and day after gavage administration to rats. The mixture is irritating to skin and eyes but an inhalation study to address possible irritation potential in the respiratory tract is lacking. For this reason and as no systemic NOAEL was obtained, a MAK value could not be derived and the substance is assigned to Section II b of the List of MAK and BAT Values. In the screening study, no adverse effects on fertility of the parental animals or on development of the progeny were observed up to the highest dose of 100 mg/kg body weight and day. The substance is not genotoxic in vitro and studies in vivo as well as carcinogenicity studies are not available. There are no clinical results on contact sensitization in humans and no unequivocally positive sensitization tests in animals. The amount of skin absorption was not investigated and could not be calculated.

Abstract

The German Commission for the Investigation of Health Hazards of Chemical Compounds in the Work Area has evaluated alkyl amines, C11‐14‐branched, monohexyl and dihexyl phosphates to derive a maximum concentration at the workplace (MAK value), considering all toxicity endpoints. In a screening study according to OECD Test Guideline 422, inflammation in the lymph nodes and the adrenals was seen at the lowest dose of 10 mg/kg body weight and day after gavage administration to rats. The mixture is irritating to skin and eyes but an inhalation study to address possible irritation potential in the respiratory tract is lacking. For this reason and as no systemic NOAEL was obtained, a MAK value could not be derived and the substance is assigned to Section II b of the List of MAK and BAT Values. In the screening study, no adverse effects on fertility of the parental animals or on development of the progeny were observed up to the highest dose of 100 mg/kg body weight and day. The substance is not genotoxic in vitro and studies in vivo as well as carcinogenicity studies are not available. There are no clinical results on contact sensitization in humans and no unequivocally positive sensitization tests in animals. The amount of skin absorption was not investigated and could not be calculated.

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Item Type:Journal Article, not_refereed, original work
Communities & Collections:04 Faculty of Medicine > Institute of Pharmacology and Toxicology
07 Faculty of Science > Institute of Pharmacology and Toxicology
Dewey Decimal Classification:570 Life sciences; biology
610 Medicine & health
Language:German
Date:26 January 2017
Deposited On:18 Oct 2019 07:29
Last Modified:23 Oct 2019 14:53
Publisher:Wiley-VCH Verlag
ISSN:2509-2383
ISBN:9783527600410
OA Status:Closed
Publisher DOI:https://doi.org/10.1002/3527600418.mb8093962ksd0062

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