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2,4,6-Tribromphenol [MAK Value Documentation in German language, 2017]


Hartwig, A; MAK Commission; et al; Arand, Michael (2017). 2,4,6-Tribromphenol [MAK Value Documentation in German language, 2017]. The MAK Collection for Occupational Health and Safety, 2(2):986-1014.

Abstract

The German Commission for the Investigation of Health Hazards of Chemical Compounds in the Work Area has evaluated 2,4,6‐tribromophenol [118‐79‐6] to derive a maximum concentration at the workplace (MAK value), considering all toxicity endpoints. Available study reports and publications are described in detail.
2,4,6‐Tribromophenol is irritating to the rabbit eye. Therefore, irritation of the respiratory tract has to be assumed; however, the only available repeated dose inhalation study in rats is of limited validity. The lowest NOAEL for systemic toxicity in an oral study in rats was 100 mg/kg body weight and day. Beginning from 300 mg/kg body weight and day, increased creatinine levels in the blood of male rats and intense salivation in male and female animals were observed. Due to the irritant potential and the lack of a valid inhalation study, no MAK value could be set and 2,4,6‐tribromophenol is classified in Section II b of the List of MAK and BAT Values.
In a reproduction and developmental toxicity screening test the NOAEL for fertility and foetotoxicity was 300 mg/kg KG body weight and day. Teratogenicity was not investigated.
2,4,6‐Tribromophenol is not regarded to be genotoxic or carcinogenic. Sensitization is not expected due to limited animal studies and human experience. Skin contact is not expected to contribute significantly to the systemic toxicity.

Abstract

The German Commission for the Investigation of Health Hazards of Chemical Compounds in the Work Area has evaluated 2,4,6‐tribromophenol [118‐79‐6] to derive a maximum concentration at the workplace (MAK value), considering all toxicity endpoints. Available study reports and publications are described in detail.
2,4,6‐Tribromophenol is irritating to the rabbit eye. Therefore, irritation of the respiratory tract has to be assumed; however, the only available repeated dose inhalation study in rats is of limited validity. The lowest NOAEL for systemic toxicity in an oral study in rats was 100 mg/kg body weight and day. Beginning from 300 mg/kg body weight and day, increased creatinine levels in the blood of male rats and intense salivation in male and female animals were observed. Due to the irritant potential and the lack of a valid inhalation study, no MAK value could be set and 2,4,6‐tribromophenol is classified in Section II b of the List of MAK and BAT Values.
In a reproduction and developmental toxicity screening test the NOAEL for fertility and foetotoxicity was 300 mg/kg KG body weight and day. Teratogenicity was not investigated.
2,4,6‐Tribromophenol is not regarded to be genotoxic or carcinogenic. Sensitization is not expected due to limited animal studies and human experience. Skin contact is not expected to contribute significantly to the systemic toxicity.

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Additional indexing

Item Type:Journal Article, not_refereed, original work
Communities & Collections:04 Faculty of Medicine > Institute of Pharmacology and Toxicology
07 Faculty of Science > Institute of Pharmacology and Toxicology
Dewey Decimal Classification:570 Life sciences; biology
610 Medicine & health
Language:German
Date:31 May 2017
Deposited On:18 Oct 2019 07:47
Last Modified:18 Oct 2019 07:48
Publisher:Wiley-VCH Verlag
ISSN:2509-2383
ISBN:9783527600410
OA Status:Closed
Publisher DOI:https://doi.org/10.1002/3527600418.mb11879d0063

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