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N′-(3-Aminopropyl)-N′-dodecylpropan-1,3-diamin [MAK Value Documentation in German language, 2017]


Hartwig, A; MAK Commission; et al; Arand, Michael (2017). N′-(3-Aminopropyl)-N′-dodecylpropan-1,3-diamin [MAK Value Documentation in German language, 2017]. The MAK Collection for Occupational Health and Safety, 2(3):1192-1225.

Abstract

The German Commission for the Investigation of Health Hazards of Chemical Compounds in the Work Area has evaluated N‐(3‐aminopropyl)‐N‐dodecylpropane‐1,3‐diamine [2372‐82‐9] to derive a maximum concentration at the workplace (MAK value), considering all toxicity endpoints. Available unpublished study reports and publications are described in detail. Critical effects are degeneration of heart muscle cells and lympho‐histiocytic infiltrations in the skeletal muscles of male rats. No NOAEL could be derived for these effects. The LOAEL is 4 mg/kg body weight. A NAEL of 1.3 mg/kg body weight was extrapolated and a MAK value of 0.05 mg/m3 for the inhalable fraction could be derived. The derivation of the MAK value is conservative because the determined oral absorption is very low and for the inhalative absorption a default value of 100 % is assumed due to a lack of experimental data. N‐(3‐Aminopropyl)‐N‐dodecylpropane‐1,3‐diamine is basic and therefore corrosive to rabbit skin, hence an irritation potential for the respiratory tract has to be assumed. No inhalation studies are available. Compared to several primary, secondary and tertiary amines which have MAK values between 1 and 13 mg/m3, the basicity of N‐(3‐aminopropyl)‐N‐dodecylpropane‐1,3‐diamine is almost the same or less. Therefore, a MAK value of 0.05 mg/m3 should protect against local irritating effects. As the critical effect is systemic, the substance has been classified in Peak Limitation Category II. An excursion factor of 8 is set as the half‐life in blood is at least 28.5 hours. The NOAELs for developmental toxicity in rats and rabbits are 22.5 and 9 mg/kg body weight and day, respectively, which can be scaled to concentrations of 1 and 0.66 mg/m3 at the workplace. Thus, there is no reason to fear damage to the embryo or foetus when the MAK value is observed and the substance is classified in Pregnancy Risk Group C. N‐(3‐Aminopropyl)‐N‐dodecylpropane‐1,3‐diamine is not genotoxic or carcinogenic. The potential of contact sensitization in humans cannot be definitely assessed because of the corrosive character. The substance is not a contact sensitizer in guinea pigs. Skin contact is not expected to contribute significantly to systemic toxicity

Abstract

The German Commission for the Investigation of Health Hazards of Chemical Compounds in the Work Area has evaluated N‐(3‐aminopropyl)‐N‐dodecylpropane‐1,3‐diamine [2372‐82‐9] to derive a maximum concentration at the workplace (MAK value), considering all toxicity endpoints. Available unpublished study reports and publications are described in detail. Critical effects are degeneration of heart muscle cells and lympho‐histiocytic infiltrations in the skeletal muscles of male rats. No NOAEL could be derived for these effects. The LOAEL is 4 mg/kg body weight. A NAEL of 1.3 mg/kg body weight was extrapolated and a MAK value of 0.05 mg/m3 for the inhalable fraction could be derived. The derivation of the MAK value is conservative because the determined oral absorption is very low and for the inhalative absorption a default value of 100 % is assumed due to a lack of experimental data. N‐(3‐Aminopropyl)‐N‐dodecylpropane‐1,3‐diamine is basic and therefore corrosive to rabbit skin, hence an irritation potential for the respiratory tract has to be assumed. No inhalation studies are available. Compared to several primary, secondary and tertiary amines which have MAK values between 1 and 13 mg/m3, the basicity of N‐(3‐aminopropyl)‐N‐dodecylpropane‐1,3‐diamine is almost the same or less. Therefore, a MAK value of 0.05 mg/m3 should protect against local irritating effects. As the critical effect is systemic, the substance has been classified in Peak Limitation Category II. An excursion factor of 8 is set as the half‐life in blood is at least 28.5 hours. The NOAELs for developmental toxicity in rats and rabbits are 22.5 and 9 mg/kg body weight and day, respectively, which can be scaled to concentrations of 1 and 0.66 mg/m3 at the workplace. Thus, there is no reason to fear damage to the embryo or foetus when the MAK value is observed and the substance is classified in Pregnancy Risk Group C. N‐(3‐Aminopropyl)‐N‐dodecylpropane‐1,3‐diamine is not genotoxic or carcinogenic. The potential of contact sensitization in humans cannot be definitely assessed because of the corrosive character. The substance is not a contact sensitizer in guinea pigs. Skin contact is not expected to contribute significantly to systemic toxicity

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Item Type:Journal Article, not_refereed, original work
Communities & Collections:04 Faculty of Medicine > Institute of Pharmacology and Toxicology
07 Faculty of Science > Institute of Pharmacology and Toxicology
Dewey Decimal Classification:570 Life sciences; biology
610 Medicine & health
Language:German
Date:26 July 2017
Deposited On:18 Oct 2019 07:34
Last Modified:18 Oct 2019 07:35
Publisher:Wiley-VCH Verlag
ISSN:2509-2383
ISBN:9783527600410
OA Status:Closed
Publisher DOI:https://doi.org/10.1002/3527600418.mb237282d0063

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