Header

UZH-Logo

Maintenance Infos

N,N-Bis(2-ethylhexyl)-((1,2,4-triazol-1-yl)methyl)amin [MAK Value Documentation in German language, 2017]


Hartwig, A; MAK Commission; et al; Arand, Michael (2017). N,N-Bis(2-ethylhexyl)-((1,2,4-triazol-1-yl)methyl)amin [MAK Value Documentation in German language, 2017]. The MAK Collection for Occupational Health and Safety, 2(2):499-515.

Abstract

The German Commission for the Investigation of Health Hazards of Chemical Compounds in the Work Area has evaluated N,N‐Bis(2‐ethylhexyl)‐((1,2,4‐triazol‐1‐yl)methyl)amine [91273‐04‐0] to derive a maximum concentration at the workplace (MAK value), considering all toxicity endpoints. Available unpublished study reports and publications are described in detail. N,N‐Bis(2‐ethylhexyl)‐((1,2,4‐triazol‐1‐yl)methyl)amine is corrosive to the skin of rabbits and results in irritation of the stomach after gavage administration in rats. Therefore, a local irritation potential is to be assumed. There are no inhalation studies availabe and no read‐across substance could be found. Thus, a MAK value could not be derived and the substance is classified in Section II b of the List of MAK and BAT Values. N,N‐Bis(2‐ethylhexyl)‐((1,2,4‐triazol‐1‐yl)methyl)amine is not genotoxic. Carcinogenicity studies are not available. Maximization tests in guinea pigs reveal a skin sensitizing potential and the substance is designated with „Sh“. Skin contact is not expected to contribute significantly to systemic toxicity.

Abstract

The German Commission for the Investigation of Health Hazards of Chemical Compounds in the Work Area has evaluated N,N‐Bis(2‐ethylhexyl)‐((1,2,4‐triazol‐1‐yl)methyl)amine [91273‐04‐0] to derive a maximum concentration at the workplace (MAK value), considering all toxicity endpoints. Available unpublished study reports and publications are described in detail. N,N‐Bis(2‐ethylhexyl)‐((1,2,4‐triazol‐1‐yl)methyl)amine is corrosive to the skin of rabbits and results in irritation of the stomach after gavage administration in rats. Therefore, a local irritation potential is to be assumed. There are no inhalation studies availabe and no read‐across substance could be found. Thus, a MAK value could not be derived and the substance is classified in Section II b of the List of MAK and BAT Values. N,N‐Bis(2‐ethylhexyl)‐((1,2,4‐triazol‐1‐yl)methyl)amine is not genotoxic. Carcinogenicity studies are not available. Maximization tests in guinea pigs reveal a skin sensitizing potential and the substance is designated with „Sh“. Skin contact is not expected to contribute significantly to systemic toxicity.

Statistics

Citations

Dimensions.ai Metrics

Altmetrics

Additional indexing

Item Type:Journal Article, not_refereed, original work
Communities & Collections:04 Faculty of Medicine > Institute of Pharmacology and Toxicology
07 Faculty of Science > Institute of Pharmacology and Toxicology
Dewey Decimal Classification:570 Life sciences; biology
610 Medicine & health
Language:German
Date:31 May 2017
Deposited On:18 Oct 2019 08:02
Last Modified:18 Oct 2019 08:02
Publisher:Wiley-VCH Verlag
ISSN:2509-2383
ISBN:9783527600410
OA Status:Closed
Publisher DOI:https://doi.org/10.1002/3527600418.mb9127304ksd0063

Download

Full text not available from this repository.
View at publisher

Get full-text in a library