Header

UZH-Logo

Maintenance Infos

Diphenylamin, octyliert (Benzolamin, N-Phenyl-, Reaktionsprodukte mit 2,4,4-Trimethylpenten) [MAK Value Documentation in German language, 2017]


Hartwig, A; MAK Commission; et al; Arand, Michael (2017). Diphenylamin, octyliert (Benzolamin, N-Phenyl-, Reaktionsprodukte mit 2,4,4-Trimethylpenten) [MAK Value Documentation in German language, 2017]. The MAK Collection for Occupational Health and Safety, 2(2):549-561.

Abstract

The German Commission for the Investigation of Health Hazards of Chemical Compounds in the Work Area has evaluated octylated diphenylamine [68411‐46‐1] to derive a maximum concentration at the workplace (MAK value), considering all toxicity endpoints. Available unpublished study reports and publications are described in detail. The critical effect of octylated diphenylamine is hepatotoxicity after repeated gavage administration to rats. Octylated diphenylamine is a UVCB‐substance, a substance of unknown or variable composition, complex reaction products or biological materials. A representative composition is not known. Thus, a MAK value could not be derived and the substance is classified in Section II b of the List of MAK and BAT Values. The substance is not genotoxic. Carcinogenicity studies and data on the potential of contact sensitization in humans are not available. The substance is not a contact sensitizer in guinea pigs. Skin contact is not expected to contribute significantly to systemic toxicity.

Abstract

The German Commission for the Investigation of Health Hazards of Chemical Compounds in the Work Area has evaluated octylated diphenylamine [68411‐46‐1] to derive a maximum concentration at the workplace (MAK value), considering all toxicity endpoints. Available unpublished study reports and publications are described in detail. The critical effect of octylated diphenylamine is hepatotoxicity after repeated gavage administration to rats. Octylated diphenylamine is a UVCB‐substance, a substance of unknown or variable composition, complex reaction products or biological materials. A representative composition is not known. Thus, a MAK value could not be derived and the substance is classified in Section II b of the List of MAK and BAT Values. The substance is not genotoxic. Carcinogenicity studies and data on the potential of contact sensitization in humans are not available. The substance is not a contact sensitizer in guinea pigs. Skin contact is not expected to contribute significantly to systemic toxicity.

Statistics

Citations

Dimensions.ai Metrics

Altmetrics

Additional indexing

Item Type:Journal Article, not_refereed, original work
Communities & Collections:04 Faculty of Medicine > Institute of Pharmacology and Toxicology
07 Faculty of Science > Institute of Pharmacology and Toxicology
Dewey Decimal Classification:570 Life sciences; biology
610 Medicine & health
Language:German
Date:31 May 2017
Deposited On:18 Oct 2019 07:57
Last Modified:18 Oct 2019 07:58
Publisher:Wiley-VCH Verlag
ISSN:2509-2383
ISBN:9783527600410
OA Status:Closed
Publisher DOI:https://doi.org/10.1002/3527600418.mb6841146ksd0063

Download

Full text not available from this repository.
View at publisher

Get full-text in a library