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3-(3,5-Di-tert-butyl-4-hydroxyphenyl)-N′-[3-(3,5-di-tert-butyl-4-hydroxyphenyl)propanoyl]propanhydrazid [MAK Value Documentation in German language, 2017]


Hartwig, A; MAK Commission; et al; Arand, Michael (2017). 3-(3,5-Di-tert-butyl-4-hydroxyphenyl)-N′-[3-(3,5-di-tert-butyl-4-hydroxyphenyl)propanoyl]propanhydrazid [MAK Value Documentation in German language, 2017]. The MAK Collection for Occupational Health and Safety, 2(2):537-548.

Abstract

The German Commission for the Investigation of Health Hazards of Chemical Compounds in the Work Area has evaluated 3‐(3,5‐di‐tert‐butyl‐4‐hydroxyphenyl)‐N′‐[3‐(3,5‐di‐tert‐butyl‐4‐hydroxyphenyl)propanoyl]‐propanehydrazide [32687‐78‐8] to derive a maximum concentration at the workplace (MAK value), considering all toxicity endpoints. The substance has a low toxicity after repeated oral administration to rats. It is not irritating to skin or eyes. The oral absorption is not known, but is assumed to be significantly less than 100% due to the high molecular mass; however, a MAK value could not be calculated from the oral studies. Therefore, the substance is assigned to Section II b of the List of MAK and BAT Values. No developmental toxicity was observed up to the highest dose of 3000 mg/kg body weight and day in rats. The substance is not genotoxic in vitro or in vivo. Carcinogenicity studies are not available. There are no clinical results on contact sensitization in humans and the substance is not sensitizing in two sensitization test in guinea pigs. Skin absorption was calculated to be so low that it will not contribute significantly to the systemic toxicity.

Abstract

The German Commission for the Investigation of Health Hazards of Chemical Compounds in the Work Area has evaluated 3‐(3,5‐di‐tert‐butyl‐4‐hydroxyphenyl)‐N′‐[3‐(3,5‐di‐tert‐butyl‐4‐hydroxyphenyl)propanoyl]‐propanehydrazide [32687‐78‐8] to derive a maximum concentration at the workplace (MAK value), considering all toxicity endpoints. The substance has a low toxicity after repeated oral administration to rats. It is not irritating to skin or eyes. The oral absorption is not known, but is assumed to be significantly less than 100% due to the high molecular mass; however, a MAK value could not be calculated from the oral studies. Therefore, the substance is assigned to Section II b of the List of MAK and BAT Values. No developmental toxicity was observed up to the highest dose of 3000 mg/kg body weight and day in rats. The substance is not genotoxic in vitro or in vivo. Carcinogenicity studies are not available. There are no clinical results on contact sensitization in humans and the substance is not sensitizing in two sensitization test in guinea pigs. Skin absorption was calculated to be so low that it will not contribute significantly to the systemic toxicity.

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Additional indexing

Item Type:Journal Article, not_refereed, original work
Communities & Collections:04 Faculty of Medicine > Institute of Pharmacology and Toxicology
07 Faculty of Science > Institute of Pharmacology and Toxicology
Dewey Decimal Classification:570 Life sciences; biology
610 Medicine & health
Language:German
Date:31 May 2017
Deposited On:18 Oct 2019 07:49
Last Modified:18 Oct 2019 07:51
Publisher:Wiley-VCH Verlag
ISSN:2509-2383
ISBN:9783527600410
OA Status:Closed
Publisher DOI:https://doi.org/10.1002/3527600418.mb3268778ksd0063

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