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Naphthalin [BAT Value Documentation in German language, 2016]


Klotz, K; Drexler, H; Hartwig, A; MAK Commission; et al; Arand, Michael (2016). Naphthalin [BAT Value Documentation in German language, 2016]. The MAK Collection for Occupational Health and Safety, 1(4):2697-2714.

Abstract

The German Commission for the Investigation of Health Hazards of Chemical Compounds in the Work Area has evaluated a BAR (“Biologischer Arbeitsstoff Referenzwert”) for naphthalene, considering 1‐ and 2‐naphthol in urine to characterize the internal exposure. Naphthalene is classified in category 2 for carcinogenic substances and designated with an “H” because of its contribution to the toxicological hazards due to penetration through the skin in vitro and dermal absorption in vivo.

In a number of biomonitoring studies, the excretion of 1‐ and 2‐naphthol in urine of persons occupationally not exposed to naphthalene was examined. Tobacco smoking affects the naphthol excretion significantly, thus non‐smokers and smokers have to be considered separately. Up to now, no data of representative collectives of the German general population are available. Therefore, the largest German study was considered for the evaluation, where urine samples of 95 non‐smokers were analysed and a 95th percentile for the sum of 1‐ and 2‐naphthol (after hydrolysis) of 33.6 µg/l (30.6 µg/g creatinine) was found. These results are in good accordance with other national and international studies. Therefore, a BAR of 35 µg 1‐ plus 2‐naphthol (after hydrolysis)/l urine was evaluated for non‐smokers. Sampling time is at the end of exposure or the end of the working shift and after long term exposure at the end of the working shift after several shifts. For the interpretation of the result, the smoking status of the persons has to be considered. In case of an occupational co‐exposure to other polycyclic aromatic hydrocarbons (PAH), the analysis of additional PAH‐metabolites is recommended (see MAK Documentation “Polycyclic Aromatic Hydrocarbons”).

Abstract

The German Commission for the Investigation of Health Hazards of Chemical Compounds in the Work Area has evaluated a BAR (“Biologischer Arbeitsstoff Referenzwert”) for naphthalene, considering 1‐ and 2‐naphthol in urine to characterize the internal exposure. Naphthalene is classified in category 2 for carcinogenic substances and designated with an “H” because of its contribution to the toxicological hazards due to penetration through the skin in vitro and dermal absorption in vivo.

In a number of biomonitoring studies, the excretion of 1‐ and 2‐naphthol in urine of persons occupationally not exposed to naphthalene was examined. Tobacco smoking affects the naphthol excretion significantly, thus non‐smokers and smokers have to be considered separately. Up to now, no data of representative collectives of the German general population are available. Therefore, the largest German study was considered for the evaluation, where urine samples of 95 non‐smokers were analysed and a 95th percentile for the sum of 1‐ and 2‐naphthol (after hydrolysis) of 33.6 µg/l (30.6 µg/g creatinine) was found. These results are in good accordance with other national and international studies. Therefore, a BAR of 35 µg 1‐ plus 2‐naphthol (after hydrolysis)/l urine was evaluated for non‐smokers. Sampling time is at the end of exposure or the end of the working shift and after long term exposure at the end of the working shift after several shifts. For the interpretation of the result, the smoking status of the persons has to be considered. In case of an occupational co‐exposure to other polycyclic aromatic hydrocarbons (PAH), the analysis of additional PAH‐metabolites is recommended (see MAK Documentation “Polycyclic Aromatic Hydrocarbons”).

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Additional indexing

Item Type:Journal Article, not_refereed, original work
Communities & Collections:04 Faculty of Medicine > Institute of Pharmacology and Toxicology
07 Faculty of Science > Institute of Pharmacology and Toxicology
Dewey Decimal Classification:570 Life sciences; biology
610 Medicine & health
Language:German
Date:26 October 2016
Deposited On:18 Oct 2019 08:34
Last Modified:18 Oct 2019 08:53
Publisher:Wiley-VCH Verlag
ISSN:2509-2383
ISBN:9783527600410
OA Status:Closed
Publisher DOI:https://doi.org/10.1002/3527600418.bb9120d0022

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