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Addendum zu Nitrobenzol [BAT Value Documentation in German language, 2017]


Leng, G; Bolt, HM; Drexler, H; Hartwig, A; MAK Commission; et al; Arand, Michael (2017). Addendum zu Nitrobenzol [BAT Value Documentation in German language, 2017]. The MAK Collection for Occupational Health and Safety, 2(3):1368-1371.

Abstract

The German Commission for the Investigation of Health Hazards of Chemical Compounds in the Work Area has re‐evaluated nitrobenzene (CAS No 98‐95‐3) in 2016, considering aniline released from aniline‐haemoglobin conjugate to characterize the internal exposure and the methaemoglobin formation as critical effect.
After inhalative exposure, high nitrobenzene concentrations cause adenomas and carcinomas in liver, kidney and thyroid in rats as well as lung and mamma in mice. A MAK value of 0.1 ml nitrobenzene/m3 was established. For the haemoglobin adduct of nitrobenzene, a BLW (biological guidance value) of 100 µg aniline (released from aniline‐haemoglobin conjugate)/l blood corresponding to a methaemoglobin formation of 5 % was evaluated based on field studies.

Abstract

The German Commission for the Investigation of Health Hazards of Chemical Compounds in the Work Area has re‐evaluated nitrobenzene (CAS No 98‐95‐3) in 2016, considering aniline released from aniline‐haemoglobin conjugate to characterize the internal exposure and the methaemoglobin formation as critical effect.
After inhalative exposure, high nitrobenzene concentrations cause adenomas and carcinomas in liver, kidney and thyroid in rats as well as lung and mamma in mice. A MAK value of 0.1 ml nitrobenzene/m3 was established. For the haemoglobin adduct of nitrobenzene, a BLW (biological guidance value) of 100 µg aniline (released from aniline‐haemoglobin conjugate)/l blood corresponding to a methaemoglobin formation of 5 % was evaluated based on field studies.

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Item Type:Journal Article, not_refereed, original work
Communities & Collections:04 Faculty of Medicine > Institute of Pharmacology and Toxicology
07 Faculty of Science > Institute of Pharmacology and Toxicology
Dewey Decimal Classification:570 Life sciences; biology
610 Medicine & health
Language:German
Date:31 July 2017
Deposited On:18 Oct 2019 07:33
Last Modified:18 Oct 2019 07:33
Publisher:Wiley-VCH Verlag
ISSN:2509-2383
ISBN:9783527600410
OA Status:Closed
Publisher DOI:https://doi.org/10.1002/3527600418.bb9895d0023

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