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Dichlormethan, Addendum [BAT Value Documentation in German language, 2016]


Bolt, H M; Weistenhöfer, W; Drexler, H; Hartwig, A; MAK Commission; et al; Arand, Michael (2016). Dichlormethan, Addendum [BAT Value Documentation in German language, 2016]. The MAK Collection for Occupational Health and Safety, 1(4):2677-2680.

Abstract

The German Commission for the Investigation of Health Hazards of Chemical Compounds in the Work Area has re‐evaluated dichloromethane, considering dichloromethane in blood to characterize the internal exposure.

In a chamber study, 14 non‐smokers were exposed to different concentrations of dichloromethane. After exposure to the present MAK‐value of 50 ml dichloromethane/m3 without physical activity, a concentration of 0.3 mg dichloromethane/l blood was measured. Considering an increased intake due to elevated breathing volume during work, the exposure to 50 ml dichloromethane/m3 results in a blood concentration of 0.5 mg/l. Taking into account this study and the EKA correlation of 2001, a BAT‐value of 500 µg dichloromethane/l blood was evaluated. Sampling time is straight after exposure.

Abstract

The German Commission for the Investigation of Health Hazards of Chemical Compounds in the Work Area has re‐evaluated dichloromethane, considering dichloromethane in blood to characterize the internal exposure.

In a chamber study, 14 non‐smokers were exposed to different concentrations of dichloromethane. After exposure to the present MAK‐value of 50 ml dichloromethane/m3 without physical activity, a concentration of 0.3 mg dichloromethane/l blood was measured. Considering an increased intake due to elevated breathing volume during work, the exposure to 50 ml dichloromethane/m3 results in a blood concentration of 0.5 mg/l. Taking into account this study and the EKA correlation of 2001, a BAT‐value of 500 µg dichloromethane/l blood was evaluated. Sampling time is straight after exposure.

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Additional indexing

Item Type:Journal Article, not_refereed, original work
Communities & Collections:04 Faculty of Medicine > Institute of Pharmacology and Toxicology
07 Faculty of Science > Institute of Pharmacology and Toxicology
Dewey Decimal Classification:570 Life sciences; biology
610 Medicine & health
Language:German
Date:26 October 2016
Deposited On:18 Oct 2019 08:19
Last Modified:18 Oct 2019 08:22
Publisher:Wiley-VCH Verlag
ISSN:2509-2383
ISBN:9783527600410
OA Status:Closed
Publisher DOI:https://doi.org/10.1002/3527600418.bb7509d0022

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