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Addendum zu Arsen und anorganische Arsenverbindungen (mit Ausnahme von Arsenwasserstoff) [BAT Value Documentation in German language, 2016]


Ochsmann, E; Göen, T; Michalke, B; Weistenhöfer, W; Klotz, K; Drexler, H; Hartwig, A; MAK Commission; et al; Arand, Michael (2016). Addendum zu Arsen und anorganische Arsenverbindungen (mit Ausnahme von Arsenwasserstoff) [BAT Value Documentation in German language, 2016]. The MAK Collection for Occupational Health and Safety, 1(3):2065-2074.

Abstract

Arsenic and inorganic arsenic compounds (with the exception of arsenic hydride): BAT value documentation (2016)

The German Commission for the Investigation of Health Hazards of Chemical Compounds in the Work Area has re‐evaluated the “Biologischer Arbeitsstoff‐Referenzwert” (BAR) as well as the exposure equivalents for carcinogenic substances (EKA) for arsenic and inorganic arsenic compounds (with the exception of arsenic hydride). Available publications are described in detail.

The quantification of the various arsenic species is essential to understand the hazardous potential of the arsenic compounds which differ highly in their toxicity. Therefore the BAR for the sum of different arsenic species is no longer valid. Considering published data from occupational not exposed persons, new BAR for the arsenic species of 0.5 μg/l urine for arsenic (+III), 0.5 μg/l urine for arsenic (+V), 2 μg/l urine for monomethylarsonic acid (MMA) and 10 μg/l urine for dimethylarsinic acid (DMA) were evaluated. The differentiation of arsenic species now allows for the estimation of the individual health risks taking into account special influences like seafood consumption. Sampling time is at the end of exposure or the end of the working shift and after long term exposure at the end of the working shift after several shifts.

Data of a correlation of arsenic in the air and the sum of the arsenic species in urine were considered for the evaluation of the exposure equivalents for carcinogenic substances. This correlation is in good accordance with the EKA correlation of arsenic trioxide, which is based on former studies in which also the urinary concentrations of the sum of As (+III), As (+V), MMA and DMA were measured. Sampling time is at the end of exposure or the end of the working shift and after long term exposure at the end of the working shift after several shifts.

Abstract

Arsenic and inorganic arsenic compounds (with the exception of arsenic hydride): BAT value documentation (2016)

The German Commission for the Investigation of Health Hazards of Chemical Compounds in the Work Area has re‐evaluated the “Biologischer Arbeitsstoff‐Referenzwert” (BAR) as well as the exposure equivalents for carcinogenic substances (EKA) for arsenic and inorganic arsenic compounds (with the exception of arsenic hydride). Available publications are described in detail.

The quantification of the various arsenic species is essential to understand the hazardous potential of the arsenic compounds which differ highly in their toxicity. Therefore the BAR for the sum of different arsenic species is no longer valid. Considering published data from occupational not exposed persons, new BAR for the arsenic species of 0.5 μg/l urine for arsenic (+III), 0.5 μg/l urine for arsenic (+V), 2 μg/l urine for monomethylarsonic acid (MMA) and 10 μg/l urine for dimethylarsinic acid (DMA) were evaluated. The differentiation of arsenic species now allows for the estimation of the individual health risks taking into account special influences like seafood consumption. Sampling time is at the end of exposure or the end of the working shift and after long term exposure at the end of the working shift after several shifts.

Data of a correlation of arsenic in the air and the sum of the arsenic species in urine were considered for the evaluation of the exposure equivalents for carcinogenic substances. This correlation is in good accordance with the EKA correlation of arsenic trioxide, which is based on former studies in which also the urinary concentrations of the sum of As (+III), As (+V), MMA and DMA were measured. Sampling time is at the end of exposure or the end of the working shift and after long term exposure at the end of the working shift after several shifts.

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Item Type:Journal Article, not_refereed, original work
Communities & Collections:04 Faculty of Medicine > Institute of Pharmacology and Toxicology
07 Faculty of Science > Institute of Pharmacology and Toxicology
Dewey Decimal Classification:570 Life sciences; biology
610 Medicine & health
Language:German
Date:25 July 2016
Deposited On:18 Oct 2019 08:45
Last Modified:18 Oct 2019 08:47
Publisher:Wiley-VCH Verlag
ISSN:2509-2383
ISBN:9783527600410
OA Status:Closed
Publisher DOI:https://doi.org/10.1002/3527600418.bb744038verd0022

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