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Addendum zu 2-Butoxyethylacetat [BAT Value Documentation in German language, 2016]


Göen, T; Rettenmeier, A W; Drexler, H; Hartwig, A; MAK Commission; et al; Arand, Michael (2016). Addendum zu 2-Butoxyethylacetat [BAT Value Documentation in German language, 2016]. The MAK Collection for Occupational Health and Safety, 1(3):2088.

Abstract

2‐Butoxyethylacetate (Ethylene glycol monobutyl ether acetate): Addendum BAT value documentation (2016)

The German Commission for the Investigation of Health Hazards of Chemical Compounds in the Work Area has re‐evaluated the biological tolerance value at the work place (BAT value) for 2‐butoxyethylacetate (ethylene glycol monobutyl ether acetate), considering butoxyacetic acid in urine to characterize the internal exposure.

Due to the high variability of conjugated amounts of the butoxyacetic acid and the limitation of conjugated amounts at high exposure levels the previous BAT value for free 2‐butoxyacetic acid is converted with a factor of 1.5. Additionally, the impact of diuresis is considered by the relation to the creatinine concentration.

Therefore, a BAT value for the total butoxyacetic acid excretion of 150 mg butoxyacetic acid (after hydrolysis)/g creatinine was established. The sampling time is at the end of exposure/shift after several previous shifts. As the effects of the two glycol ethers 2‐butoxyethyl acetate and 2‐butoxyethanol are largely the same in the human organism, the BAT value applies to both and for combined exposure. The two substances were discussed together in the addendum of 2‐butoxyethanol.

Abstract

2‐Butoxyethylacetate (Ethylene glycol monobutyl ether acetate): Addendum BAT value documentation (2016)

The German Commission for the Investigation of Health Hazards of Chemical Compounds in the Work Area has re‐evaluated the biological tolerance value at the work place (BAT value) for 2‐butoxyethylacetate (ethylene glycol monobutyl ether acetate), considering butoxyacetic acid in urine to characterize the internal exposure.

Due to the high variability of conjugated amounts of the butoxyacetic acid and the limitation of conjugated amounts at high exposure levels the previous BAT value for free 2‐butoxyacetic acid is converted with a factor of 1.5. Additionally, the impact of diuresis is considered by the relation to the creatinine concentration.

Therefore, a BAT value for the total butoxyacetic acid excretion of 150 mg butoxyacetic acid (after hydrolysis)/g creatinine was established. The sampling time is at the end of exposure/shift after several previous shifts. As the effects of the two glycol ethers 2‐butoxyethyl acetate and 2‐butoxyethanol are largely the same in the human organism, the BAT value applies to both and for combined exposure. The two substances were discussed together in the addendum of 2‐butoxyethanol.

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Additional indexing

Item Type:Journal Article, not_refereed, original work
Communities & Collections:04 Faculty of Medicine > Institute of Pharmacology and Toxicology
07 Faculty of Science > Institute of Pharmacology and Toxicology
Dewey Decimal Classification:570 Life sciences; biology
610 Medicine & health
Language:German
Date:25 July 2016
Deposited On:18 Oct 2019 08:37
Last Modified:18 Oct 2019 08:42
Publisher:Wiley-VCH Verlag
ISSN:2509-2383
ISBN:9783527600410
OA Status:Closed
Publisher DOI:https://doi.org/10.1002/3527600418.bb11207d0022

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