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Ethylbenzol, Addendum [BAT Value Documentation in German language, 2016]


Reuter, U; Göen, T; Drexler, H; Hartwig, A; MAK Commission; et al; Arand, Michael (2016). Ethylbenzol, Addendum [BAT Value Documentation in German language, 2016]. The MAK Collection for Occupational Health and Safety, 1(4):2681-2685.

Abstract

The German Commission for the Investigation of Health Hazards of Chemical Compounds in the Work Area has re‐evaluated the biological tolerance value at the work place (BAT value) and the exposure equivalents for carcinogenic substances (EKA) for ethylbenzene, considering mandelic acid and phenylglyoxylic acid in urine as well as 2‐ and 4‐ethylphenol in urine (after hydrolysis) to characterize the internal exposure. Ethylbenzene was classified in category 4 for carcinogenic substances. It can easily pass through the skin, so biological monitoring is necessary for a valid individual risk assessment.

The BAT value for styrene, which also considers the sum of mandelic acid and phenylglyoxylic acid, was evaluated as creatinine related value. For practical reasons, the BAT value and the EKA for ethylbenzene are transformed into creatinine related values as well. Therefore, volume‐related results of studies were re‐calculated using a conversion factor of 1.2 g creatinine/l urine. The available studies are in good accordance. A BAT value for the sum of mandelic acids plus phenylglyoxylic acid of 250 mg/g creatinine was evaluated. Sampling should be performed at the end of exposure or end of the shift.

For the EKA correlation, the values for the parameter mandelic acid plus phenylglyoxylic acid were also re‐calculated using a conversion factor of 1.2 g creatinine/l urine. Sampling time is at the end of exposure or end of the shift. For the parameter 2‐plus 4‐ethylphenol, data differ in the two available older studies. While in one study only 2‐ethylphenol was found as metabolite of ethylbenzene, in the other study only 4‐ethylphenol was determined. In a more recent study, solely 4‐ethylphenol, but no 2‐ethylphenol could be analysed. Because of the inconsistency of the data, the EKA for the parameter 2‐ plus 4‐ethylphenol is withdrawn.

Abstract

The German Commission for the Investigation of Health Hazards of Chemical Compounds in the Work Area has re‐evaluated the biological tolerance value at the work place (BAT value) and the exposure equivalents for carcinogenic substances (EKA) for ethylbenzene, considering mandelic acid and phenylglyoxylic acid in urine as well as 2‐ and 4‐ethylphenol in urine (after hydrolysis) to characterize the internal exposure. Ethylbenzene was classified in category 4 for carcinogenic substances. It can easily pass through the skin, so biological monitoring is necessary for a valid individual risk assessment.

The BAT value for styrene, which also considers the sum of mandelic acid and phenylglyoxylic acid, was evaluated as creatinine related value. For practical reasons, the BAT value and the EKA for ethylbenzene are transformed into creatinine related values as well. Therefore, volume‐related results of studies were re‐calculated using a conversion factor of 1.2 g creatinine/l urine. The available studies are in good accordance. A BAT value for the sum of mandelic acids plus phenylglyoxylic acid of 250 mg/g creatinine was evaluated. Sampling should be performed at the end of exposure or end of the shift.

For the EKA correlation, the values for the parameter mandelic acid plus phenylglyoxylic acid were also re‐calculated using a conversion factor of 1.2 g creatinine/l urine. Sampling time is at the end of exposure or end of the shift. For the parameter 2‐plus 4‐ethylphenol, data differ in the two available older studies. While in one study only 2‐ethylphenol was found as metabolite of ethylbenzene, in the other study only 4‐ethylphenol was determined. In a more recent study, solely 4‐ethylphenol, but no 2‐ethylphenol could be analysed. Because of the inconsistency of the data, the EKA for the parameter 2‐ plus 4‐ethylphenol is withdrawn.

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Additional indexing

Item Type:Journal Article, not_refereed, original work
Communities & Collections:04 Faculty of Medicine > Institute of Pharmacology and Toxicology
07 Faculty of Science > Institute of Pharmacology and Toxicology
Dewey Decimal Classification:570 Life sciences; biology
610 Medicine & health
Language:German
Date:26 October 2016
Deposited On:18 Oct 2019 08:36
Last Modified:18 Oct 2019 08:44
Publisher:Wiley-VCH Verlag
ISSN:2509-2383
ISBN:9783527600410
OA Status:Closed
Publisher DOI:https://doi.org/10.1002/3527600418.bb10041d0022

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