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Self-reported neurocognitive impairment in people living with HIV: Characterizing clusters of patients with similar changes in self-reported neurocognitive impairment 2013-2017 in the Swiss HIV Cohort Study


Kusejko, Katharina; Salazar-Vizcaya, Luisa; Braun, Dominique L; Tarr, Philip E; Bernasconi, Enos; Doco-Lecompte, Thanh; Cavassini, Matthias; Schmid, Patrick; Du Pasquier, Renaud; Hauser, Christoph; Günthard, Huldrych F; Kouyos, Roger D; Swiss HIV Cohort Study (2020). Self-reported neurocognitive impairment in people living with HIV: Characterizing clusters of patients with similar changes in self-reported neurocognitive impairment 2013-2017 in the Swiss HIV Cohort Study. Clinical Infectious Diseases, 71(3):637-644.

Abstract

INTRODUCTION
Self-reported neurocognitive impairment (srni) in people living with human immunodeficiency virus-1 (HIV-1) infection are frequent. We use longitudinal information on srni in the Swiss HIV Cohort Study (SHCS) to identify and characterize groups of patients with persisting srni over time.
METHODS
We included all SHCS patients who were assessed for srni during at least 5 visits spanning at least 2.5 years in 2013-2017. We first compared patients with srni to those without srni over the whole study period. Second, we used a hierarchical cluster algorithm to identify groups of patients with similar changes of srni over time. In both analyses, we studied clinical and demographic factors potentially influencing srni.
RESULTS
In total, 79'683 questionnaires of 11'029 patients contained information about srni, and 8'545/11'029 (77.5%) patients had longitudinal information. The overall percentage of patients with srni decreased from 19.6% in 2013 to 10.7% in 2017. Compared to patients in the cluster with low-level srni over time, patients in the cluster with high-level persisting srni had more often a prior opportunistic infection of the central nervous system (CNS) (OR=3.7, p<0.001), imperfect adherence to antiretroviral treatment (ART) (OR=2.8, p<0.001) and a depression (OR=1.9, p<0.001).
CONCLUSIONS
Although overall srni is decreasing in the SHCS, there is a group of patients with persisting srni over time. Past opportunistic infections of the CNS, imperfect adherence to ART as well as depression were associated most with persisting srni. Patients with these characteristics should be preferentially tested for neurocognitive impairment.

Abstract

INTRODUCTION
Self-reported neurocognitive impairment (srni) in people living with human immunodeficiency virus-1 (HIV-1) infection are frequent. We use longitudinal information on srni in the Swiss HIV Cohort Study (SHCS) to identify and characterize groups of patients with persisting srni over time.
METHODS
We included all SHCS patients who were assessed for srni during at least 5 visits spanning at least 2.5 years in 2013-2017. We first compared patients with srni to those without srni over the whole study period. Second, we used a hierarchical cluster algorithm to identify groups of patients with similar changes of srni over time. In both analyses, we studied clinical and demographic factors potentially influencing srni.
RESULTS
In total, 79'683 questionnaires of 11'029 patients contained information about srni, and 8'545/11'029 (77.5%) patients had longitudinal information. The overall percentage of patients with srni decreased from 19.6% in 2013 to 10.7% in 2017. Compared to patients in the cluster with low-level srni over time, patients in the cluster with high-level persisting srni had more often a prior opportunistic infection of the central nervous system (CNS) (OR=3.7, p<0.001), imperfect adherence to antiretroviral treatment (ART) (OR=2.8, p<0.001) and a depression (OR=1.9, p<0.001).
CONCLUSIONS
Although overall srni is decreasing in the SHCS, there is a group of patients with persisting srni over time. Past opportunistic infections of the CNS, imperfect adherence to ART as well as depression were associated most with persisting srni. Patients with these characteristics should be preferentially tested for neurocognitive impairment.

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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > Institute of Medical Virology
04 Faculty of Medicine > University Hospital Zurich > Clinic for Infectious Diseases
Dewey Decimal Classification:610 Medicine & health
Language:English
Date:27 July 2020
Deposited On:31 Oct 2019 09:21
Last Modified:29 Jul 2020 11:34
Publisher:Oxford University Press
ISSN:1058-4838
OA Status:Closed
Free access at:Publisher DOI. An embargo period may apply.
Publisher DOI:https://doi.org/10.1093/cid/ciz868
PubMed ID:31504323

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