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Hard tissue changes after guided bone regeneration of peri-implant defects comparing block versus particulate bone substitutes: 6-month results of a randomized controlled clinical trial


Benic, Goran I; Eisner, Barbara M; Jung, Ronald E; Basler, Tobias; Schneider, David; Hämmerle, Christoph H F (2019). Hard tissue changes after guided bone regeneration of peri-implant defects comparing block versus particulate bone substitutes: 6-month results of a randomized controlled clinical trial. Clinical Oral Implants Research, 30(10):1016-1026.

Abstract

OBJECTIVES
To test whether block bone substitute used for guided bone regeneration (GBR) of peri-implant defects leads to different thickness of the augmented hard tissue than particulate bone substitute.
MATERIAL AND METHODS
In 24 patients, 24 two-piece dental implants were placed >4 months after tooth extraction. Following random allocation, 12 peri-implant bone dehiscences were grafted with an individually shaped block of deproteinized bovine-derived bone mineral (DBBM) and 12 bone dehiscences with particulate DBBM. All the sites were covered with a collagen membrane stabilized with resorbable pins. Immediately after wound closure and after 6 months, the horizontal thickness (HT) of the augmented hard tissue was measured at the level of implant shoulder using cone beam-computed tomography.
RESULTS
After wound closure, the median HT measured 3.35 mm (mean: 3.38) in the block group and 2.85 mm (mean: 2.73) in the particulate group. At 6 months, the median HT decreased to 2.90 mm (mean: 2.71) in the block group and to 0.2 mm (mean: 0.52) in the particulate group. This difference was statistically significant (p < .001).
CONCLUSIONS
Block bone substitute used for GBR of peri-implant defects was superior to particulate bone substitute regarding the dimension of the augmented hard tissue after 6 months of healing.

Abstract

OBJECTIVES
To test whether block bone substitute used for guided bone regeneration (GBR) of peri-implant defects leads to different thickness of the augmented hard tissue than particulate bone substitute.
MATERIAL AND METHODS
In 24 patients, 24 two-piece dental implants were placed >4 months after tooth extraction. Following random allocation, 12 peri-implant bone dehiscences were grafted with an individually shaped block of deproteinized bovine-derived bone mineral (DBBM) and 12 bone dehiscences with particulate DBBM. All the sites were covered with a collagen membrane stabilized with resorbable pins. Immediately after wound closure and after 6 months, the horizontal thickness (HT) of the augmented hard tissue was measured at the level of implant shoulder using cone beam-computed tomography.
RESULTS
After wound closure, the median HT measured 3.35 mm (mean: 3.38) in the block group and 2.85 mm (mean: 2.73) in the particulate group. At 6 months, the median HT decreased to 2.90 mm (mean: 2.71) in the block group and to 0.2 mm (mean: 0.52) in the particulate group. This difference was statistically significant (p < .001).
CONCLUSIONS
Block bone substitute used for GBR of peri-implant defects was superior to particulate bone substitute regarding the dimension of the augmented hard tissue after 6 months of healing.

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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > Center for Dental Medicine > Clinic of Reconstructive Dentistry
Dewey Decimal Classification:610 Medicine & health
Language:English
Date:October 2019
Deposited On:05 Nov 2019 13:59
Last Modified:06 Nov 2019 08:34
Publisher:Wiley-Blackwell Publishing, Inc.
ISSN:0905-7161
OA Status:Closed
Publisher DOI:https://doi.org/10.1111/clr.13515
PubMed ID:31332835

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