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Listening to tissues with new light: recent technological advances in photoacoustic imaging

Vu, Tri; Razansky, Daniel; Yao, Junjie (2019). Listening to tissues with new light: recent technological advances in photoacoustic imaging. Journal of Optics, 21(10):103001.

Abstract

Photoacoustic tomography (PAT), or optoacoustic tomography, has achieved remarkable progress in the past decade, benefiting from the joint developments in optics, acoustics, chemistry, computing and mathematics. Unlike pure optical or ultrasound imaging, PAT can provide unique optical absorption contrast as well as widely scalable spatial resolution, penetration depth and imaging speed. Moreover, PAT has inherent sensitivity to tissue's functional, molecular, and metabolic state. With these merits, PAT has been applied in a wide range of life science disciplines, and has enabled biomedical research unattainable by other imaging methods. This review article aims at introducing state-of-the-art PAT technologies and their representative applications. The focus is on recent technological breakthroughs in structural, functional, molecular PAT, including super-resolution imaging, real-time small-animal whole-body imaging, and high-sensitivity functional/molecular imaging. We also discuss the remaining challenges in PAT and envisioned opportunities.

Additional indexing

Item Type:Journal Article, refereed, further contribution
Communities & Collections:04 Faculty of Medicine > Institute of Pharmacology and Toxicology
07 Faculty of Science > Institute of Pharmacology and Toxicology

04 Faculty of Medicine > Institute of Biomedical Engineering
Dewey Decimal Classification:170 Ethics
610 Medicine & health
Scopus Subject Areas:Physical Sciences > Electronic, Optical and Magnetic Materials
Physical Sciences > Atomic and Molecular Physics, and Optics
Uncontrolled Keywords:Atomic and Molecular Physics, and Optics, Electronic, Optical and Magnetic Materials
Language:English
Date:1 October 2019
Deposited On:04 Nov 2019 11:07
Last Modified:20 Jun 2025 01:40
Publisher:IOP Publishing
ISSN:2040-8986
OA Status:Closed
Publisher DOI:https://doi.org/10.1088/2040-8986/ab3b1a

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