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Nitroethane [MAK value documentation, 2017]


Hartwig, A; MAK Commission; Arand, Michael; et al (2019). Nitroethane [MAK value documentation, 2017]. The MAK Collection for Occupational Health and Safety, 4(3):1178-1200.

Abstract

The German Commission for the Investigation of Health Hazards of Chemical Compounds in the Work Area has re‐evaluated the maximum concentration at the workplace (MAK value) for nitroethane [79‐24‐3], considering the endpoints local and systemic toxicity as well as developmental toxicity. Nitroethane acts locally as well as systemically. A 13‐week study in rats and mice found significantly increased methaemoglobin levels accompanied by changes in the spleen as critical effects. A NOAEC was not obtained. Based on the LOAEC of 100 ml/m3 and taking into consideration the higher sensitivity of humans and the possibility of effects increasing with time, the MAK value for nitroethane is lowered to 10 ml/m3. Degeneration, inflammation and hyperplasia of the olfactory epithelium occur at higher exposure concentrations. As the critical effect is systemic, the assignment to Peak Limitation Category II is retained as well as the excursion factor of 4. Because there are no studies on developmental toxicity with pure nitroethane, the assignment to Pregnancy Risk Group D is also confirmed. Skin contact may contribute significantly to systemic toxicity and nitroethane is designated with an “H”. Sensitization is not expected from the limited data.

Abstract

The German Commission for the Investigation of Health Hazards of Chemical Compounds in the Work Area has re‐evaluated the maximum concentration at the workplace (MAK value) for nitroethane [79‐24‐3], considering the endpoints local and systemic toxicity as well as developmental toxicity. Nitroethane acts locally as well as systemically. A 13‐week study in rats and mice found significantly increased methaemoglobin levels accompanied by changes in the spleen as critical effects. A NOAEC was not obtained. Based on the LOAEC of 100 ml/m3 and taking into consideration the higher sensitivity of humans and the possibility of effects increasing with time, the MAK value for nitroethane is lowered to 10 ml/m3. Degeneration, inflammation and hyperplasia of the olfactory epithelium occur at higher exposure concentrations. As the critical effect is systemic, the assignment to Peak Limitation Category II is retained as well as the excursion factor of 4. Because there are no studies on developmental toxicity with pure nitroethane, the assignment to Pregnancy Risk Group D is also confirmed. Skin contact may contribute significantly to systemic toxicity and nitroethane is designated with an “H”. Sensitization is not expected from the limited data.

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Additional indexing

Item Type:Journal Article, not_refereed, original work
Communities & Collections:04 Faculty of Medicine > Institute of Pharmacology and Toxicology
07 Faculty of Science > Institute of Pharmacology and Toxicology
Dewey Decimal Classification:570 Life sciences; biology
610 Medicine & health
Language:German
Date:25 July 2019
Deposited On:22 Nov 2019 15:47
Last Modified:06 Dec 2019 04:17
Publisher:Wiley-VCH Verlag
ISSN:2509-2383
ISBN:9783527600410
OA Status:Closed
Publisher DOI:https://doi.org/10.1002/3527600418.mb7924e6319

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