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Oxalsäuredinitril [MAK value documentation in German language, 2019]


Hartwig, A; MAK Commission; Arand, Michael; et al (2019). Oxalsäuredinitril [MAK value documentation in German language, 2019]. The MAK Collection for Occupational Health and Safety, 4(3):1533-1536.

Abstract

German Commission for the Investigation of Health Hazards of Chemical Compounds in the Work Area has re‐evaluated the maximum concentration at the workplace (MAK value) and the Pregnancy Risk Group of oxalonitrile [460‐19‐5].
There are no new data. The MAK value of 5 ml/m3 was determined in analogy to the more toxic metabolite hydrogen cyanide. The MAK value for hydrogen cyanide of 1.9 ml/m3 was derived from the human detoxification capacity per kg body weight with a respiratory volume of 10 m3. Therefore, the increased respiratory volume at the workplace has already been accounted for. The MAK value of oxalonitrile, which was set at 5 ml/m3 to reflect the 2.5‐fold higher acute toxicity of hydrogen cyanide, can be retained. This is also the case for Peak Limitation Category II and the excursion factor of 2 because no irritation was observed in humans below 16 ml/m3.
There are no developmental toxicity studies. Therefore, oxalonitrile is assigned to Pregnancy Risk Group D.

Abstract

German Commission for the Investigation of Health Hazards of Chemical Compounds in the Work Area has re‐evaluated the maximum concentration at the workplace (MAK value) and the Pregnancy Risk Group of oxalonitrile [460‐19‐5].
There are no new data. The MAK value of 5 ml/m3 was determined in analogy to the more toxic metabolite hydrogen cyanide. The MAK value for hydrogen cyanide of 1.9 ml/m3 was derived from the human detoxification capacity per kg body weight with a respiratory volume of 10 m3. Therefore, the increased respiratory volume at the workplace has already been accounted for. The MAK value of oxalonitrile, which was set at 5 ml/m3 to reflect the 2.5‐fold higher acute toxicity of hydrogen cyanide, can be retained. This is also the case for Peak Limitation Category II and the excursion factor of 2 because no irritation was observed in humans below 16 ml/m3.
There are no developmental toxicity studies. Therefore, oxalonitrile is assigned to Pregnancy Risk Group D.

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Additional indexing

Item Type:Journal Article, not_refereed, original work
Communities & Collections:04 Faculty of Medicine > Institute of Pharmacology and Toxicology
07 Faculty of Science > Institute of Pharmacology and Toxicology
Dewey Decimal Classification:570 Life sciences; biology
610 Medicine & health
Language:German
Date:1 August 2019
Deposited On:22 Nov 2019 15:49
Last Modified:04 Dec 2019 16:04
Publisher:Wiley-VCH Verlag
ISSN:2509-2383
ISBN:9783527600410
OA Status:Closed
Publisher DOI:https://doi.org/10.1002/3527600418.mb46019d0067

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