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Titandioxid (alveolengängige Fraktion) [MAK Value Documentation in German language, 2019]


Hartwig, A; MAK Commission; Arand, Michael; et al (2019). Titandioxid (alveolengängige Fraktion) [MAK Value Documentation in German language, 2019]. The MAK Collection for Occupational Health and Safety, 4(2):857-869.

Abstract

The German Commission for the Investigation of Health Hazards of Chemical Compounds in the Work Area has re‐evaluated titanium dioxide [13463‐67‐1]. Titanium dioxide causes lung tumours in rats at high concentrations. In 2009, titanium dioxide was evaluated and, because a maximum concentration at the workplace (MAK value) could not be established, it was classified in Carcinogen Category 3A. Titanium dioxide is a biopersistent granular dust and, in a later evaluation, inhalation studies with titanium dioxide were used to derive the general threshold limit value for granular biopersistent dusts. Therefore, the respirable fraction of titanium dioxide dust is reclassified in Carcinogen Category 4 and a MAK value of 0.3 mg/m3 × material density is established for the respirable fraction according to the general threshold value for biopersistent granular dusts. Reclassification in Carcinogen Category 4 is justified because the lung tumours are regarded as a consequence of the inflammatory mechanism of action, for which a threshold can be defined. Direct genotoxic effects appear to be of subordinate relevance for the carcinogenicity of biopersistent granular dusts. By analogy with the biopersistent granular dusts, Peak Limitation Category II is established for titanium dioxide with an excursion factor of 8. Since titanium dioxide is not systemically distributed and accumulates only locally in the lungs, damage to the embryo or foetus is unlikely when the MAK value is not exceeded. Titanium dioxide is classified accordingly in Pregnancy Risk Group C. Titanium dioxide is not expected to be a sensitizer and is not taken up via the skin in toxicologically relevant amounts.

Abstract

The German Commission for the Investigation of Health Hazards of Chemical Compounds in the Work Area has re‐evaluated titanium dioxide [13463‐67‐1]. Titanium dioxide causes lung tumours in rats at high concentrations. In 2009, titanium dioxide was evaluated and, because a maximum concentration at the workplace (MAK value) could not be established, it was classified in Carcinogen Category 3A. Titanium dioxide is a biopersistent granular dust and, in a later evaluation, inhalation studies with titanium dioxide were used to derive the general threshold limit value for granular biopersistent dusts. Therefore, the respirable fraction of titanium dioxide dust is reclassified in Carcinogen Category 4 and a MAK value of 0.3 mg/m3 × material density is established for the respirable fraction according to the general threshold value for biopersistent granular dusts. Reclassification in Carcinogen Category 4 is justified because the lung tumours are regarded as a consequence of the inflammatory mechanism of action, for which a threshold can be defined. Direct genotoxic effects appear to be of subordinate relevance for the carcinogenicity of biopersistent granular dusts. By analogy with the biopersistent granular dusts, Peak Limitation Category II is established for titanium dioxide with an excursion factor of 8. Since titanium dioxide is not systemically distributed and accumulates only locally in the lungs, damage to the embryo or foetus is unlikely when the MAK value is not exceeded. Titanium dioxide is classified accordingly in Pregnancy Risk Group C. Titanium dioxide is not expected to be a sensitizer and is not taken up via the skin in toxicologically relevant amounts.

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Additional indexing

Item Type:Journal Article, not_refereed, original work
Communities & Collections:04 Faculty of Medicine > Institute of Pharmacology and Toxicology
07 Faculty of Science > Institute of Pharmacology and Toxicology
Dewey Decimal Classification:570 Life sciences; biology
610 Medicine & health
Language:German
Date:25 April 2019
Deposited On:21 Nov 2019 15:38
Last Modified:05 Dec 2019 08:20
Publisher:Wiley-VCH Verlag
ISSN:2509-2383
ISBN:9783527600410
OA Status:Closed
Publisher DOI:https://doi.org/10.1002/3527600418.mb1346367d0067

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